{"id":292,"date":"2015-11-16T08:51:06","date_gmt":"2015-11-16T13:51:06","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?page_id=292"},"modified":"2019-03-06T10:05:56","modified_gmt":"2019-03-06T15:05:56","slug":"henry-f-frierson-jr-m-d","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/pathology\/contact\/henry-f-frierson-jr-m-d\/","title":{"rendered":"Henry F. Frierson, Jr., M.D."},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-903 size-medium\" src=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/FriersonHenry-e1528208209599-225x300.jpg\" alt=\"Henry F. Frierson, Jr., M.D.\" width=\"225\" height=\"300\" srcset=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/FriersonHenry-e1528208209599-225x300.jpg 225w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/FriersonHenry-e1528208209599-113x150.jpg 113w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/FriersonHenry-e1528208209599-768x1024.jpg 768w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><br \/>\nProfessor of Pathology<br \/>\nDirector of Cytopathology<\/p>\n<h4>EDUCATION:<\/h4>\n<p><span class=\"wdcfontSize2\"><strong>College:<\/strong> Davidson College, 1977, B.S.<br \/>\n<strong>Medical School:<\/strong> Medical University\u00a0of South Carolina , 1981, M.D.<br \/>\n<strong>Residency:<\/strong> University of Virginia (AP\/CP), 1981-1985<\/span><\/p>\n<h4>CLINICAL:<\/h4>\n<p>I provide service in Cytopathology and Surgical Pathology.In addition,I have performed international volunteer services in pathology in the following countries: St. Lucia, Peru, Belize, and Nicaragua.<\/p>\n<h4>RESEARCH:<\/h4>\n<p>I have a special interest in mouse models of prostate cancer, and have characterized the phenotypes of about a dozen genotypes that include genetic alterations of PTEN,MYC,TGFBR2,SMAD2,APC,and AKT, among others.<\/p>\n<h4>REFERENCES:<\/h4>\n<ul>\n<li>Bjerke GA, Yang YS, <strong>Frierson HF<\/strong>, Paschal BM, Wotton D: Activation of Akt signaling in prostate induces a TGFB-mediated restraint on cancer progression and metastasis. Oncogene (in press)<\/li>\n<li>Overdevest JB, Knubel KH, Duex JB, Thomas S, Nitz MD, Harding MA, Smith SC, <strong>Frierson, HF<\/strong>, Conaway M, Theodorescu D: CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated. Proc Natl Acad Sci USA 109:E3588-E3596, 2012.<\/li>\n<li>Persson M, Andren Y, Moskaluk CA, <strong>Frierson HF Jr<\/strong>, Cooke SL, Futreal PA, Kling T, Nelander S, Nordkvist A, Persson F, Stenman G: Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. Genes Chromosomes Cancer 51: 805-817, 2012.<\/li>\n<li>Zhang Y, Gong M, Yuan H, Park HG, <strong>Frierson HF<\/strong>, Li H: Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation. Cancer Discov 2:598-607, 2012.<\/li>\n<li>DeGraff DJ, Clark PE, Cates JM, Yamashita H, Robinson VL, Yu X, Smolkin ME, Chang SS, Cookson MS, Herrick MK, Shariat SF, Steinberg GD, <strong>Frierson HF<\/strong>, Wu X-R, Theodorescu D, Matusik RJ: Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation. PloS One 7:e366669, 2012.<\/li>\n<li>Moskaluk CA, Baras AS, Mancuso SA, Fan H, Davidson RJ, Dirks DC, Golden WL, <strong>Frierson HF Jr<\/strong>: Development and characterization of xenograft model systems for adenoid cystic carcinoma. Lab Invest 91: 1480-1490, 2011.<\/li>\n<li>Brill LB 2<sup>nd<\/sup>, Kanner WA, Fehr A, Andren Y, Moskaluk CA, Loning T, Stenman G, <strong>Frierson HF Jr<\/strong>: Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 24: 1169-1176, 2011.<\/li>\n<li>Fehr A, Kovacs A, Loning T, <strong>Frierson H Jr<\/strong>, van den Oord J, Stenman G: The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. J Pathol 224: 322-327, 2011.<\/li>\n<\/ul>\n<p>A complete list of Dr. Frierson&#8217;s peer-reviewed publications can be obtained from <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=PureSearch&amp;db=pubmed&amp;details_term=(Frierson%20HF[author%20name])%20OR%20(Frierson%20H[author%20name])\">PubMed<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Professor of Pathology Director of Cytopathology EDUCATION: College: Davidson College, 1977, B.S. Medical School: Medical University\u00a0of South Carolina , 1981, M.D. Residency: University of Virginia (AP\/CP), 1981-1985 CLINICAL: I provide service in Cytopathology and Surgical Pathology.In addition,I have performed international volunteer services in pathology in the following countries: St. Lucia, Peru, Belize, and Nicaragua. RESEARCH: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":14,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-292","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Henry F. 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