{"id":341,"date":"2015-11-16T11:16:17","date_gmt":"2015-11-16T16:16:17","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?page_id=341"},"modified":"2020-03-25T14:31:43","modified_gmt":"2020-03-25T18:31:43","slug":"james-w-mandell-m-d","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/pathology\/contact\/james-w-mandell-m-d\/","title":{"rendered":"James W. Mandell, M.D., Ph.D."},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"Portrait alignnone wp-image-875 size-medium\" src=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2016\/03\/MandellJames-225x300.jpg\" alt=\"James W. Mandell, M.D.\" width=\"225\" height=\"300\" srcset=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2016\/03\/MandellJames-225x300.jpg 225w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2016\/03\/MandellJames-e1528208652985-112x150.jpg 112w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2016\/03\/MandellJames-768x1024.jpg 768w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><br \/>\nProfessor, Division of Neuropathology<br \/>\nMember, Neuroscience Graduate Program<br \/>\nAssociate Director for Curriculum, Medical Scientist Training Program<\/p>\n<h4>EDUCATION:<\/h4>\n<p><strong>Medical School:<\/strong> M.D.\/Ph.D. Cornell University Medical College, New York, NY.\u00a0 MD, 1992<br \/>\n<strong>Graduate School:<\/strong> Postdoctoral Fellow,\u00a0 Department of Neuroscience, Laboratory of Dr. Gary Banker, University of Virginia, 1992 &#8211; 1994<br \/>\n<strong>Residency:<\/strong> Anatomic Pathology, University of Virginia, 1994 &#8211; 1996<br \/>\n<strong>Fellowship:<\/strong> Fellow, Neuropathology, University of Virginia, 1996 &#8211; 1998<\/p>\n<h3>CLINICAL:<\/h3>\n<h4>Clinical Interests:<\/h4>\n<p>Surgical and Autopsy Diagnostic Neuropathology<br \/>\nNeuromuscular Pathology<br \/>\nOphthalmic Pathology<br \/>\nIn addition to shared coverage of the\u00a0Diagnostic Surgical and Autopsy Neuropathology service, I\u00a0am the sole faculty member responsible for all neuromuscular biopsy diagnosis as well as for all ophthalmic pathology \u00a0diagnosis.<\/p>\n<h4>RESEARCH:<\/h4>\n<p>Currently my research program has two funded projects. \u00a0The first is focused on discovering and validating biomarkers of synaptic degeneration, using a global proteomics screening platform. \u00a0The second seeks to identify novel biomarkers of inflammatory myopathies, especially inclusion body myositis, focusing on noncoding RNAs that can be detected both in muscle biopsies as well as in the circulation. \u00a0We have developed a novel multiplex immunhistochemistry platform (patent application pending) that should have broad utility in anatomic pathology and seek new collaborative projects.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-345 size-full\" src=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/mandellab.jpg\" alt=\"mandel lab\" width=\"630\" height=\"360\" srcset=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/mandellab.jpg 630w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2015\/11\/mandellab-300x171.jpg 300w\" sizes=\"(max-width: 630px) 100vw, 630px\" \/><\/p>\n<h4>REFERENCES:<\/h4>\n<ul>\n<li>\u00a0Chen CJ, Williams EA, McAneney TE, Williams BJ, <strong>Mandell JW<\/strong>, Shaffrey ME: Histiocytic sarcoma of the cavernous sinus: case report and literature review. Brain Tumor Pathol 2015, 32:66-71.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24807104\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24807104<\/u><\/a>. DOI: 10.1007\/s10014-014-0191-3.<\/li>\n<li>\u00a0Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, <strong>Mandell JW<\/strong>, Lee KS, Harris TH, Kipnis J: Structural and functional features of central nervous system lymphatic vessels. Nature 2015, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26030524\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26030524<\/u><\/a>. DOI: 10.1038\/nature14432.<\/li>\n<li>Sokolowski JD, Gamage KK, Heffron DS, Leblanc AC, Deppmann CD, <strong>Mandell JW<\/strong>: Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta Neuropathol Commun 2014, 2:16. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24507707\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24507707<\/u><\/a>. DOI: 10.1186\/2051-5960-2-16.<\/li>\n<li>Nacey NC, Almira Suarez MI, <strong>Mandell JW<\/strong>, Anderson MW, Gaskin CM: Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings. Skeletal Radiol 2014, 43:375-379. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24061494\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24061494<\/u><\/a>. DOI: 10.1007\/s00256-013-1733-1.<\/li>\n<li>\u00a0Sokolowski JD, Chabanon-Hicks C, Han CZ, Heffron DS, <strong>Mandell JW<\/strong>: Fractalkine is a &#8220;find-me&#8221; signal released by neurons undergoing ethanol-induced apoptosis. Front Cell Neurosci 2014, 8:360.<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25426022\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25426022<\/u><\/a>. DOI: 10.3389\/fncel.2014.00360.<\/li>\n<li>\u00a0Hochreiter-Hufford A, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, <strong>Mandell JW<\/strong>, Ravichandran KS: Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature 2013, 497:263-267. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23615608\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23615608<\/u><\/a>. DOI: 10.1038\/nature12135.<\/li>\n<li>Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, <strong>Mandell J<\/strong>, Abounader R: A novel PTEN\/mutant p53\/c-Myc\/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. Neoplasia 2013, 15:952-965. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23908595\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23908595<\/u><\/a>.<\/li>\n<li><strong>Mandell J<\/strong>, Heffron D, Sokolowski J: Persistence Of Apoptotic Debris In Brain-Specific Rac1-Conditional Knockouts: Evidence For A Macroglial Clearance Function. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2011, 70:528-529. <a href=\"http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=WOS:000290751700124&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=cfc784e19a5045db07524a7304ce6a05\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/gateway.webofknowledge.com\/gateway\/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=WOS:000290751700124&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=cfc784e19a5045db07524a7304ce6a05<\/u><\/a>.<\/li>\n<li>Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS, <strong>Mandell JW<\/strong>: Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun 2011, 25:915-921. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20888903\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20888903<\/u><\/a>. DOI: 10.1016\/j.bbi.2010.09.021.<\/li>\n<li>\u00a0Louis RG, Yen CP, Mohila CA, <strong>Mandell JW<\/strong>, Sheehan J: A rare intraosseous arteriovenous malformation of the spine. J Neurosurg Spine 2011, 15:336-339.<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21663404\" target=\"_blank\" rel=\"noopener noreferrer\"><u>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21663404<\/u><\/a>. DOI: 10.3171\/2011.5.SPINE10872.<\/li>\n<\/ul>\n<p>A\u00a0more complete\u00a0list of Dr.\u00a0Mandell&#8217;s publications can be obtained from <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?Db=pubmed&amp;Cmd=DetailsSearch&amp;Term=Mandell+JW[author]\">PubMed<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Professor, Division of Neuropathology Member, Neuroscience Graduate Program Associate Director for Curriculum, Medical Scientist Training Program EDUCATION: Medical School: M.D.\/Ph.D. Cornell University Medical College, New York, NY.\u00a0 MD, 1992 Graduate School: Postdoctoral Fellow,\u00a0 Department of Neuroscience, Laboratory of Dr. Gary Banker, University of Virginia, 1992 &#8211; 1994 Residency: Anatomic Pathology, University of Virginia, 1994 &#8211; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":14,"menu_order":29,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-341","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>James W. 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