{"id":385,"date":"2015-11-16T12:30:00","date_gmt":"2015-11-16T17:30:00","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?page_id=385"},"modified":"2019-05-22T17:01:03","modified_gmt":"2019-05-22T21:01:03","slug":"scott-vande-pol-m-d-ph-d","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/pathology\/contact\/scott-vande-pol-m-d-ph-d\/","title":{"rendered":"Scott Vande Pol, M.D., Ph.D."},"content":{"rendered":"

\"\"
\nAssociate Professor of Pathology<\/p>\n

Education:<\/h4>\n

1985: M.D., University of California, San Diego
\n1985: Ph.D., University of California, San Diego
\n1985-1989: Resident in Pathology, National Cancer Institute, National Institutes of Health,\u00a0 Bethesda, MD 20892
\n1989-1993: Postdoctoral Fellow, Laboratory of Tumor Virus Biology, National Cancer Institutes, Bethesda, MD 20892<\/p>\n

Research:<\/h4>\n

Our studies of the BPV-1 E6 oncoprotein found that it associated with a cellular regulatory adapter molecule called paxillin.\u00a0 We showed that paxillin was required for the tyrosine phosphorylation of Focal Adhesion Kinase, a central regulator of integrin signaling, cell attachment and migration.\u00a0 We now have evidence that paxillin is required for the activity of many cancer-associated oncoproteins. We are elucidating the role of paxillin in cancer signal transduction and survival.
\nA second project has been devoted to understanding of the mechanism by which E6 oncoproteins activate the ubiquitin mediated degradation of tumor supressor proteins, such as p53. We are engaged in a collaboration to solve the solution structure of the E6.\u00a0\u00a0 In the process of these studies, we identified interaction motifs on E6 that allow for the interaction of E6 with tumor supressors.\u00a0\u00a0\u00a0 We have recently identified a new cellular protein that is targeted for degradation by E6 together with a cellular ubiquitin ligase.\u00a0 This new target is a tyrosine phosphatase about which little is known.\u00a0 We suspect that by targeting this phosphatase for degradation, that E6 manipulates cellular signaling to facilitate the viral life cycle.\u00a0 Given that human HPV containing tumors all express E6, this phosphatase may prove to be an important target in the development of cancers, both viral positive and negative.<\/p>\n

Recent Publications<\/h4>\n