{"id":5142,"date":"2022-10-03T11:16:43","date_gmt":"2022-10-03T15:16:43","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?page_id=5142"},"modified":"2022-10-03T11:45:48","modified_gmt":"2022-10-03T15:45:48","slug":"bon-trinh-ph-d","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/pathology\/contact\/bon-trinh-ph-d\/","title":{"rendered":"Bon Trinh, Ph.D."},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5140\" src=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2022\/10\/Trinh.jpg\" alt=\"Bon Trinh, Ph.D.\" width=\"231\" height=\"254\" srcset=\"https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2022\/10\/Trinh.jpg 231w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2022\/10\/Trinh-136x150.jpg 136w, https:\/\/med.virginia.edu\/pathology\/wp-content\/uploads\/sites\/290\/2022\/10\/Trinh-182x200.jpg 182w\" sizes=\"(max-width: 231px) 100vw, 231px\" \/><br \/>\nAssistant Professor of Pathology<\/p>\n<p><strong>Education and Training:<\/strong><\/p>\n<p>2002, B.S. Biotechnology, Vietnam National University, Hanoi, Vietnam<br \/>\n2011, Ph.D. Biomedical Sciences, University of Texas Graduate School of Biomedical Sciences, Houston, TX<br \/>\n2011-2016, Postdoctoral Fellow, Systems Biology, Molecular and Cellular Oncology, University of Texas MD Anderson Cancer, Houston, TX<br \/>\n2016-2020 Research Fellow in Medicine, Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA<br \/>\n2020-2022 Instructor in Medicine, Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA<\/p>\n<p><strong>Research:<\/strong><\/p>\n<p>Myeloid cells, including granulocytes and macrophages, play a crucial role in the body&#8217;s de\u00adfense against infections. Abnormalities in their functions and maturation cause various diseases. At the Trinh laboratory, we employ experimental and computational approaches to understand how proteins and RNAs act at chromatin level to control activities of key genes involved in normal myeloid cell maturation, leukemia development, myeloid cell &#8211; cancer cell communication in the tumor microenvironment, as well as drug response. The aims are to identify actionable molecular targets and diagnostic biomarkers, and to develop innovative therapeutic strate\u00adgies for diseases such as cancer. <a href=\"https:\/\/sites.google.com\/view\/trinhlab\/research?authuser=0\">Learn more<\/a><\/p>\n<p><strong>Selected Publications:<\/strong><\/p>\n<ul>\n<li><strong>Trinh BQ<\/strong>*, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso TM, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A &amp; Tenen DG*. Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML. Blood Journal. 2021. PMID: 33971010 (*corresponding authors).<\/li>\n<li>van der Kouwe E, Heller G, Czibere A, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa MA, Pemovska T, Pichler A, Pulikkan JA, Schmolke AS, Schweicker C, Sill H, Sperr W, Spittler A, Surapally S,\u00a0<strong>Trinh BQ<\/strong>, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber BP.\u00a0Core binding factor leukemias hijack T-cell prone PU.1 antisense promoter.\u00a0Blood Journal. 2021. PMID: 34010414.<\/li>\n<li>Umarino S, Hausman C, Gaggi G, Rinaldi L, Bassal MA, Zhang Y, Seelam AJ, Kobayashi IS, Borchiellini M, Ebralidze AK, Ghinassi B,\u00a0<strong>Trinh BQ<\/strong>, Kobayashi SS, Di Ruscio A.\u00a0NAD modulates DNA methylation and cell differentiation.\u00a0<em>Cells<\/em>. 2021.\u00a0<a href=\"https:\/\/www.google.com\/url?q=https%3A%2F%2Fwww.mdpi.com%2F2073-4409%2F10%2F11%2F2986&amp;sa=D&amp;sntz=1&amp;usg=AOvVaw0an_A4qLkF-XeqBzsT4CI3\">MDPI<\/a><\/li>\n<li><strong>Trinh BQ<\/strong>, Barengo N, Kim SB, Lee JS, Naora H.\u00a0The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1b and NF-kB signaling.\u00a0Journal of Cell Science\u00a0128(16):3055-67. 2015. PMID: 26208636<\/li>\n<li><strong>Trinh BQ<\/strong>, Ko SY, Haria D, Barengo N, &amp; Naora H. The homeoprotein DLX4 controls ovarian tumor angiogenesis by regulating expression of inducible nitric oxide synthase. Molecular Cancer. Apr 30;14(1):97. 2015. PMID: 25924901<\/li>\n<li>Haria D*,\u00a0<strong>Trinh BQ*<\/strong>, Ko SY, Barengo N, Liu JS &amp; Naora H.\u00a0The homeoprotein DLX4 stimulates NF-\u03baB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer.\u00a0American Journal of Pathology\u00a0185(8):2298-308. 2015. PMID: 26067154 (*equal contribution)<\/li>\n<li><strong>Trinh BQ<\/strong>, Ko SY, Barengo N, Lin SY, Naora H.\u00a0Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.\u00a0Cancer Research\u00a073:1000-10. 2013. PMID: 23222298<\/li>\n<li><strong>Trinh BQ<\/strong>, Naora H. Homeobox genes and theirs functional significance in ovarian tumorigenesis,\u00a0<a href=\"https:\/\/www.google.com\/url?q=https%3A%2F%2Fwww.intechopen.com%2Fchapters%2F28402&amp;sa=D&amp;sntz=1&amp;usg=AOvVaw2DX9BAk2JGzs6uXIf4Ib4C\">Ovarian Cancer \/ Book 1<\/a>, ISBN 978-953-307-812-0, 2012<\/li>\n<li><strong>Trinh BQ<\/strong>, Barengo N, Naora H.\u00a0Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-b cytostatic program and blocks the anti-proliferative effect of TGF-b.\u00a0Oncogene\u00a030: 2718-2729. 2011. PMID: 21297662<\/li>\n<li>Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT,\u00a0<strong>Trinh BQ<\/strong>, Lu Z, Ueno NT, Wolf JK, Bast RC Jr, Hung MC.\u00a0A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.\u00a0Molecular Cancer Therapeutics\u00a0Aug;8(8):2375-82. 2009. PMID: 19671744<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Professor of Pathology Education and Training: 2002, B.S. Biotechnology, Vietnam National University, Hanoi, Vietnam 2011, Ph.D. Biomedical Sciences, University of Texas Graduate School of Biomedical Sciences, Houston, TX 2011-2016, Postdoctoral Fellow, Systems Biology, Molecular and Cellular Oncology, University of Texas MD Anderson Cancer, Houston, TX 2016-2020 Research Fellow in Medicine, Hematology Oncology, Beth Israel [&hellip;]<\/p>\n","protected":false},"author":1184,"featured_media":0,"parent":14,"menu_order":44,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-5142","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bon Trinh, Ph.D. - Department of Pathology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pathology\/contact\/bon-trinh-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bon Trinh, Ph.D. - Department of Pathology\" \/>\n<meta property=\"og:description\" content=\"Assistant Professor of Pathology Education and Training: 2002, B.S. 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