{"id":1449,"date":"2016-08-26T14:43:05","date_gmt":"2016-08-26T18:43:05","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?p=1449"},"modified":"2024-05-03T08:27:47","modified_gmt":"2024-05-03T12:27:47","slug":"light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\/","title":{"rendered":"Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era"},"content":{"rendered":"<p><strong>Authors:<\/strong>\u00a0Stokes MB, Valeri AM, Herlitz L, et al.<\/p>\n<p><strong>Publication:<\/strong><em> J Am Soc Nephrol<\/em> 27: 1555-1565, 2016.<\/p>\n<p>Proximal tubular cells contain cytoplasmic monoclonal immunoglobulin in the entity known as light chain proximal tubulopathy (LCPT).\u00a0 The deposits are usually crystalline, but can form globules or create vacuoles.\u00a0 This study examines the clinicopathologic characteristics of these two forms of LCPT.\u00a0 The majority of cases, (87%), were crystalline, kappa-restricted and had acute tubular injury.\u00a0 One-third of noncrystalline patients had lambda restriction or acute tubular injury.\u00a0 Antigen retrieval by immunofluorescence was frequently required to demonstrate both crystalline and noncrystalline forms.\u00a0 Electron microscopy also demonstrated crystals and granules not seen on light microscopy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors:\u00a0Stokes MB, Valeri AM, Herlitz L, et al. Publication: J Am Soc Nephrol 27: 1555-1565, 2016. Proximal tubular cells contain cytoplasmic monoclonal immunoglobulin in the entity known as light chain proximal tubulopathy (LCPT).\u00a0 The deposits are usually crystalline, but can form globules or create vacuoles.\u00a0 This study examines the clinicopathologic characteristics of these two forms [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[23],"class_list":["post-1449","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-acute-tubular-damage"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era - Department of Pathology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era - Department of Pathology\" \/>\n<meta property=\"og:description\" content=\"Authors:\u00a0Stokes MB, Valeri AM, Herlitz L, et al. Publication: J Am Soc Nephrol 27: 1555-1565, 2016. Proximal tubular cells contain cytoplasmic monoclonal immunoglobulin in the entity known as light chain proximal tubulopathy (LCPT).\u00a0 The deposits are usually crystalline, but can form globules or create vacuoles.\u00a0 This study examines the clinicopathologic characteristics of these two forms [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Pathology\" \/>\n<meta property=\"article:published_time\" content=\"2016-08-26T18:43:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-03T12:27:47+00:00\" \/>\n<meta name=\"author\" content=\"School of Medicine Webmaster\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"School of Medicine Webmaster\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pathology\\\/2016\\\/08\\\/26\\\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pathology\\\/2016\\\/08\\\/26\\\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\\\/\"},\"author\":{\"name\":\"School of Medicine Webmaster\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pathology\\\/#\\\/schema\\\/person\\\/6e677950e11557f4c0506a2b00603569\"},\"headline\":\"Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era\",\"datePublished\":\"2016-08-26T18:43:05+00:00\",\"dateModified\":\"2024-05-03T12:27:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pathology\\\/2016\\\/08\\\/26\\\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\\\/\"},\"wordCount\":118,\"keywords\":[\"Acute Tubular Damage\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pathology\\\/2016\\\/08\\\/26\\\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/pathology\\\/2016\\\/08\\\/26\\\/light-chain-proximal-tubulopathy-clinical-and-pathologic-characteristics-in-the-modern-treatment-era\\\/\",\"name\":\"Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era - 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