{"id":1451,"date":"2016-08-26T14:50:37","date_gmt":"2016-08-26T18:50:37","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?p=1451"},"modified":"2024-05-03T08:27:46","modified_gmt":"2024-05-03T12:27:46","slug":"c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/","title":{"rendered":"C3 glomerulopathy: Clinicopathologic features and predictors of outcome"},"content":{"rendered":"<p><strong>Authors:\u00a0<\/strong>Medjeral-Thomas NP, O\u2019Shaughnessy MM, O\u2019Regan JA, et al.<\/p>\n<p><strong>Publication:<\/strong>\u00a0<em>Clin J Am Soc Nephrol<\/em> 9; 46-53, 2014<\/p>\n<p>C3 glomerulopathy is characterized by intensely staining glomerular deposits of C3 in the absence of significant IgG deposits.\u00a0 This study describes the clinicopathologic features of a large British cohort of these patients.\u00a0 One-quarter of the patients had dense deposit disease (DDD) and three-quarters had C3 glomerulonephritis (C3GN). The\u00a0 DDD patients were younger, had lower C3 levels and more often had crescentic GN.\u00a0 The C3GN patients were older, and had more arteriolar sclerosis, and glomerular and interstitial damage.\u00a0 Those patients older than 16 years, who had DDD or crescents, were more likely to progress to end stage renal disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors:\u00a0Medjeral-Thomas NP, O\u2019Shaughnessy MM, O\u2019Regan JA, et al. Publication:\u00a0Clin J Am Soc Nephrol 9; 46-53, 2014 C3 glomerulopathy is characterized by intensely staining glomerular deposits of C3 in the absence of significant IgG deposits.\u00a0 This study describes the clinicopathologic features of a large British cohort of these patients.\u00a0 One-quarter of the patients had dense deposit [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[18],"class_list":["post-1451","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-dense-deposit-disease"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>C3 glomerulopathy: Clinicopathologic features and predictors of outcome - Department of Pathology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C3 glomerulopathy: Clinicopathologic features and predictors of outcome - Department of Pathology\" \/>\n<meta property=\"og:description\" content=\"Authors:\u00a0Medjeral-Thomas NP, O\u2019Shaughnessy MM, O\u2019Regan JA, et al. Publication:\u00a0Clin J Am Soc Nephrol 9; 46-53, 2014 C3 glomerulopathy is characterized by intensely staining glomerular deposits of C3 in the absence of significant IgG deposits.\u00a0 This study describes the clinicopathologic features of a large British cohort of these patients.\u00a0 One-quarter of the patients had dense deposit [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Pathology\" \/>\n<meta property=\"article:published_time\" content=\"2016-08-26T18:50:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-03T12:27:46+00:00\" \/>\n<meta name=\"author\" content=\"School of Medicine Webmaster\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"School of Medicine Webmaster\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/\",\"url\":\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/\",\"name\":\"C3 glomerulopathy: Clinicopathologic features and predictors of outcome - Department of Pathology\",\"isPartOf\":{\"@id\":\"https:\/\/med.virginia.edu\/pathology\/#website\"},\"datePublished\":\"2016-08-26T18:50:37+00:00\",\"dateModified\":\"2024-05-03T12:27:46+00:00\",\"author\":{\"@id\":\"https:\/\/med.virginia.edu\/pathology\/#\/schema\/person\/6e677950e11557f4c0506a2b00603569\"},\"breadcrumb\":{\"@id\":\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/med.virginia.edu\/pathology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"C3 glomerulopathy: Clinicopathologic features and predictors of outcome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/med.virginia.edu\/pathology\/#website\",\"url\":\"https:\/\/med.virginia.edu\/pathology\/\",\"name\":\"Department of Pathology\",\"description\":\"University of Virginia School of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/med.virginia.edu\/pathology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/med.virginia.edu\/pathology\/#\/schema\/person\/6e677950e11557f4c0506a2b00603569\",\"name\":\"School of Medicine Webmaster\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/med.virginia.edu\/pathology\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/892f3576ab4d29bd11981c3e45c61cbcf0ce3134064871521508e9a5c2450339?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/892f3576ab4d29bd11981c3e45c61cbcf0ce3134064871521508e9a5c2450339?s=96&d=mm&r=g\",\"caption\":\"School of Medicine Webmaster\"},\"description\":\"I'm the webmaster.\",\"url\":\"https:\/\/med.virginia.edu\/pathology\/author\/uvasomwebmaster\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"C3 glomerulopathy: Clinicopathologic features and predictors of outcome - Department of Pathology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/c3-glomerulopathy-clinicopathologic-features-and-predictors-of-outcome\/","og_locale":"en_US","og_type":"article","og_title":"C3 glomerulopathy: Clinicopathologic features and predictors of outcome - Department of Pathology","og_description":"Authors:\u00a0Medjeral-Thomas NP, O\u2019Shaughnessy MM, O\u2019Regan JA, et al. 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