{"id":1453,"date":"2016-08-26T14:51:49","date_gmt":"2016-08-26T18:51:49","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/?p=1453"},"modified":"2026-06-05T16:19:41","modified_gmt":"2026-06-05T20:19:41","slug":"idiopathic-nodular-glomerulosclerosis-is-a-distinct-clinicopathologic-entity-linked-to-hypertension-and-smoking","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/idiopathic-nodular-glomerulosclerosis-is-a-distinct-clinicopathologic-entity-linked-to-hypertension-and-smoking\/","title":{"rendered":"Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking"},"content":{"rendered":"

Authors:<\/strong>\u00a0Markowitz GS, Lin J, Valeri AM, et al.<\/p>\n

Publication:<\/strong>\u00a0Hum Pathol<\/em> 33: 826-835, 2002<\/a><\/p>\n

Idiopathic nodular sclerosis mimics diabetic glomerulosclerosis, but occurs in patients with no clinical evidence of diabetes mellitus.\u00a0 This study reviews a cohort of these patients biopsied between 1996 and 2001.\u00a0 The patients were more often older, Caucasian, and male.\u00a0 They presented with renal insufficiency, proteinuria often nephrotic-range, and usually had hypertension, hypercholesterolemia and were smokers.\u00a0 The renal biopsies were characterized by diffuse nodular mesangial sclerosis, thickened basement membranes and arterial sclerosis.\u00a0 Combined afferent and efferent arteriolar hyalinosis, once thought to be diagnostic of diabetic damage can also be seen. Immunofluorescence showed low intensity linear staining of all basement membranes in nearly half of the cases.<\/p>\n","protected":false},"excerpt":{"rendered":"

Authors:\u00a0Markowitz GS, Lin J, Valeri AM, et al. Publication:\u00a0Hum Pathol 33: 826-835, 2002 Idiopathic nodular sclerosis mimics diabetic glomerulosclerosis, but occurs in patients with no clinical evidence of diabetes mellitus.\u00a0 This study reviews a cohort of these patients biopsied between 1996 and 2001.\u00a0 The patients were more often older, Caucasian, and male.\u00a0 They presented with […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[14,43],"class_list":["post-1453","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-diabetes","tag-intranet"],"acf":false,"yoast_head":"\nIdiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking - Department of Pathology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pathology\/2016\/08\/26\/idiopathic-nodular-glomerulosclerosis-is-a-distinct-clinicopathologic-entity-linked-to-hypertension-and-smoking\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking - Department of Pathology\" \/>\n<meta property=\"og:description\" content=\"Authors:\u00a0Markowitz GS, Lin J, Valeri AM, et al. 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