{"id":6380,"date":"2022-09-29T17:28:11","date_gmt":"2022-09-29T21:28:11","guid":{"rendered":"https:\/\/med.virginia.edu\/pathology\/2022\/09\/29\/jeremy-shaw-phd-2020\/"},"modified":"2025-05-16T21:14:39","modified_gmt":"2025-05-17T01:14:39","slug":"jeremy-shaw-phd-2020","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pathology\/2022\/09\/29\/jeremy-shaw-phd-2020\/","title":{"rendered":"Jeremy Shaw, PhD, 2020"},"content":{"rendered":"

Evaluating the Ceramide Nanoliposome as a Therapy for Head and Neck Squamous Cell Carcinoma – Circumventing Resistance, Characterizing Death, Utilizing Dual Therapies, and Manipulating Metabolism<\/h1>\n

Advisor:<\/span><\/strong><\/h4>\n

Kester, Mark, MD-PHAR Pharmacology, University of Virginia<\/p>\n

Abstract:<\/span><\/strong><\/h4>\n
\n

Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most deadly cancer in the world. While traditional therapies are highly morbid, there have been only a few new systemic treatments developed in the last few decades, and these benefit only a small population of patients. The anti-cancer signaling sphingolipid ceramide has shown promise as a therapeutic in many cancer models including preliminary work in HNSCC. The ceramide nanoliposome (CNL) is a nanoscale, therapeutic ceramide-delivery vehicle currently in Phase I clinical trials for treating advanced solid tumors. Thus, the thesis seeks to evaluate the CNL as a potential therapeutic for HNSCC. This is accomplished by exploring methods to circumvent resistance (Chapter 2), identify novel markers of non-canonical cell death (Chapter 3), utilize synergistic dual therapeutic approaches with previously failed EGFR inhibitors (Chapter 4), and manipulate sphingolipid metabolism (Chapter 5). These studies elucidate a myriad of signaling pathways as well as specific druggable targets that can be manipulated to enhance therapeutic efficacy of CNL or other ceramide-based therapies for treatment of HNSCC.<\/p>\n<\/div>\n

Full Dissertation:<\/strong><\/h4>\n

https:\/\/doi.org\/10.18130\/v3-7acd-5g11<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Evaluating the Ceramide Nanoliposome as a Therapy for Head and Neck Squamous Cell Carcinoma – Circumventing Resistance, Characterizing Death, Utilizing Dual Therapies, and Manipulating Metabolism Advisor: Kester, Mark, MD-PHAR Pharmacology, University of Virginia Abstract: Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most deadly cancer in the world. While traditional therapies are highly […]<\/p>\n","protected":false},"author":1184,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[41],"tags":[],"class_list":["post-6380","post","type-post","status-publish","format-standard","hentry","category-phd-defenses"],"acf":false,"yoast_head":"\nJeremy Shaw, PhD, 2020 - Department of Pathology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pathology\/2022\/09\/29\/jeremy-shaw-phd-2020\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jeremy Shaw, PhD, 2020 - Department of Pathology\" \/>\n<meta property=\"og:description\" content=\"Evaluating the Ceramide Nanoliposome as a Therapy for Head and Neck Squamous Cell Carcinoma – Circumventing Resistance, Characterizing Death, Utilizing Dual Therapies, and Manipulating Metabolism Advisor: Kester, Mark, MD-PHAR Pharmacology, University of Virginia Abstract: Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most deadly cancer in the world. 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