Congratulations to the Guagliardo Lab on their recent publication in Endocrinology titled “Osmolarity Controls Oscillatory Calcium Signaling to Reduce Autonomous Aldosterone Production in Zona Glomerulosa Cells.”
Primary aldosteronism is a major contributor to hypertensive cardiovascular and renal disease and is highly prevalent—affecting 5–10% of individuals with hypertension and up to 20% of those with resistant hypertension. This work reveals how extracellular osmolarity acts as a powerful regulator of adrenal cell excitability and steroidogenesis. By demonstrating that increased osmolarity suppresses calcium oscillations and aldosterone secretion in models of primary aldosteronism, the study highlights a novel strategy for controlling aldosterone autonomy. These findings suggest that targeting volume-regulatory mechanisms could provide a novel therapeutic strategy for managing hypertension and related cardiovascular diseases.
Read the full article here:
Diagne M, Gerding MR, Breault DT, Nieh EH, Beenhakker MP, Barrett PQ, et al. Osmolarity Controls Oscillatory Calcium Signaling to Reduce Autonomous Aldosterone Production in Zona Glomerulosa Cells. Endocrinology. 2025 Dec 1;166(12):bqaf147.
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