By Disease Focus

Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders

Behavioral Pharmacology, Sex Differences, Animal Models of Addiction

Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

Molecular mechanisms controlling insulin signaling and fat synthesis.

Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

Chemical biology of sphingosine 1-phosphate

Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

Role of endoplasmic reticulum-associated protein degradation in health and disease

Translating our discoveries in the microcirculation to tangible benefits in patients.

Composition, Biophysics and Physiology of Cellular Membranes

Iron metabolism and Immunometabolism in inflammation and autoimmune diseases

Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

Sphingolipids in ocular disease and cancer

Molecular basis of ciliopathies; Signaling mechanisms of cilia-associated kinases

Chemical biology of sphingosine 1-phosphate

Identifying tumor selective drug targets, Understanding the genetic drivers of tumor immune evasion

The Ubiquitin System and Human Cancer

Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging

Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics

Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression

Composition, Biophysics and Physiology of Cellular Membranes

Chromosome segregation and aneuploidy in meiosis and mitosis

Proteoform Systems Biology: proteogenomic approaches to uncover the role of proteomic variation in human disease

Neurobiology of the cardiovascular and respiratory system, Central mechanisms linking cardiorespiratory function with affective state and emotion

Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism

Sphingolipids in ocular disease and cancer

Molecular mechanisms controlling insulin signaling and fat synthesis.

Chemical biology of sphingosine 1-phosphate

Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.

Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

Role of endoplasmic reticulum-associated protein degradation in health and disease

Iron metabolism and Immunometabolism in inflammation and autoimmune diseases

Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging

Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics

Brain metabolism, cognitive decline, cholesterol and Alzheimer's disease

Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders

Mechanisms of neuromodulation in central neurons

Circuit mechanisms of sleep and epilepsy

Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders

Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.

Neuroscience

Neurobiology of the cardiovascular and respiratory system, Central mechanisms linking cardiorespiratory function with affective state and emotion

Mechanisms of neuromodulation in central neurons

Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

Translating our discoveries in the microcirculation to tangible benefits in patients.

Identify the calcium signaling abnormalities that lead to vascular dysfunction and blood pressure elevation in cardiovascular disorders

Chemical biology of sphingosine 1-phosphate

Chemical biology of sphingosine 1-phosphate

Mechanisms of neuromodulation in central neurons

Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics

Immune response to infectious disease in the CNS