Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Molecular mechanisms controlling insulin signaling and fat synthesis.
Molecular Biology of Sphingosine 1-phosphate
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Role of Programmed Cell Death in Kidney Injury
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Central respiratory circuits, Mechanisms Underlying Breathing Complexity and Central hypoventilation syndrome
Neural Circuits in Healthy and Diseased Brains
Other PSTG Faculty
Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Brain metabolism, cognitive decline and Alzheimer's disease
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Immune response to infectious disease in the CNS
Translating our discoveries in the microcirculation to tangible benefits in patients.
Identify the calcium signaling abnormalities that lead to vascular dysfunction and blood pressure elevation in cardiovascular disorders
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.