{"id":7694,"date":"2024-11-14T19:34:26","date_gmt":"2024-11-14T19:34:26","guid":{"rendered":"https:\/\/med.virginia.edu\/pharm\/?p=7694"},"modified":"2026-05-22T20:36:57","modified_gmt":"2026-05-22T20:36:57","slug":"new-research-led-by-shengyi-iris-sun-phd-sheds-light-on-fibrinogen-biogenesis-and-hepatic-fibrinogen-storage-disease","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pharm\/2024\/11\/14\/new-research-led-by-shengyi-iris-sun-phd-sheds-light-on-fibrinogen-biogenesis-and-hepatic-fibrinogen-storage-disease\/","title":{"rendered":"New Research Led by Shengyi Iris Sun, PhD, Sheds Light on Fibrinogen Biogenesis and Hepatic Fibrinogen Storage Disease"},"content":{"rendered":"

In a recent study published in\u00a0Nature Communications,<\/a>\u00a0researchers at the University of Virginia School of Medicine led by Shengyi Iris Sun, PhD, an associate professor in the Department of Pharmacology, uncovered how one of these quality control systems, called the ER-associated degradation (ERAD) pathway, helps regulate the production and breakdown of fibrinogen, a key protein involved in blood clotting. They identified the SEL1L-HRD1 complex within the ERAD pathway as crucial for preventing a rare liver disorder, known as hepatic fibrinogen storage disease (HFSD).<\/p>\n

The researchers showed that when the SEL1L-HRD1 complex is deficient in liver cells, it leads to the formation of abnormal fibrinogen retention and deposits. They further revealed that the SEL1L-HRD1 ERAD complex mediates the breakdown misfolded fibrinogen protein components, allowing only correctly folded fibrinogen to form.<\/p>\n

\u201cOur findings highlight the importance of SEL1L-HRD1 in maintaining normal fibrinogen production,\u201d said Dr. Sun. \u201cBy clearing misfolded fibrinogen, this complex supports the healthy formation and release of this essential protein.\u201d<\/p>\n

Read more about Dr. Sun’s research here<\/a>, and at her lab website here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

In a recent study published in\u00a0Nature Communications,\u00a0researchers at the University of Virginia School of Medicine led by Shengyi Iris Sun, PhD, an associate professor in the Department of Pharmacology, uncovered how one of these quality control systems, called the ER-associated degradation (ERAD) pathway, helps regulate the production and breakdown of fibrinogen, a key protein involved […]<\/p>\n","protected":false},"author":1900,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[10],"class_list":["post-7694","post","type-post","status-publish","format-standard","hentry","category-news","tag-intranet"],"acf":false,"yoast_head":"\nNew Research Led by Shengyi Iris Sun, PhD, Sheds Light on Fibrinogen Biogenesis and Hepatic Fibrinogen Storage Disease - Department of Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pharm\/2024\/11\/14\/new-research-led-by-shengyi-iris-sun-phd-sheds-light-on-fibrinogen-biogenesis-and-hepatic-fibrinogen-storage-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Research Led by Shengyi Iris Sun, PhD, Sheds Light on Fibrinogen Biogenesis and Hepatic Fibrinogen Storage Disease - 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