{"id":7931,"date":"2025-07-21T16:56:40","date_gmt":"2025-07-21T16:56:40","guid":{"rendered":"https:\/\/med.virginia.edu\/pharm\/?p=7931"},"modified":"2025-07-21T17:59:58","modified_gmt":"2025-07-21T17:59:58","slug":"drs-ling-qi-and-shengyi-sun-publish-new-research-in-nature-cell-biology","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pharm\/2025\/07\/21\/drs-ling-qi-and-shengyi-sun-publish-new-research-in-nature-cell-biology\/","title":{"rendered":"Dr.&#8217;s Ling Qi and Shengyi Sun Publish New Research in Nature Cell Biology"},"content":{"rendered":"<p>A newly published review in Nature Cell Biology by Drs. Ling Qi and Shengyi Sun, along with postdoctoral fellow Dr. Huilun Helen Wang and collaborator Dr. Ida Biunno, provides a comprehensive overview of the SEL1L-HRD1-mediated endoplasmic reticulum-associated degradation (ERAD) pathway in mammals. This evolutionarily conserved protein quality control system is essential for maintaining ER homeostasis and regulating diverse physiological processes in a substrate-specific manner. The review highlights recent advances in the molecular machinery and functions of the SEL1L-HRD1 ERAD complex, its emerging roles in human diseases such as ERAD-associated neurodevelopmental disorders, and potential therapeutic strategies targeting this pathway.<\/p>\n<p>Wang, H.H., Biunno, I., Sun, S.\u00a0<i>et al.<\/i>\u00a0SEL1L\u2013HRD1-mediated ERAD in mammals.\u00a0<i>Nat Cell Biol<\/i>\u00a0<b>27<\/b>, 1063\u20131073 (2025). <a href=\"https:\/\/doi.org\/10.1038\/s41556-025-01690-1\">https:\/\/doi.org\/10.1038\/s41556-025-01690-1\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A newly published review in Nature Cell Biology by Drs. Ling Qi and Shengyi Sun, along with postdoctoral fellow Dr. Huilun Helen Wang and collaborator Dr. Ida Biunno, provides a comprehensive overview of the SEL1L-HRD1-mediated endoplasmic reticulum-associated degradation (ERAD) pathway in mammals. This evolutionarily conserved protein quality control system is essential for maintaining ER homeostasis [&hellip;]<\/p>\n","protected":false},"author":1900,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[],"class_list":["post-7931","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dr.&#039;s Ling Qi and Shengyi Sun Publish New Research in Nature Cell Biology - Department of Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pharm\/2025\/07\/21\/drs-ling-qi-and-shengyi-sun-publish-new-research-in-nature-cell-biology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr.&#039;s Ling Qi and Shengyi Sun Publish New Research in Nature Cell Biology - Department of Pharmacology\" \/>\n<meta property=\"og:description\" content=\"A newly published review in Nature Cell Biology by Drs. Ling Qi and Shengyi Sun, along with postdoctoral fellow Dr. Huilun Helen Wang and collaborator Dr. Ida Biunno, provides a comprehensive overview of the SEL1L-HRD1-mediated endoplasmic reticulum-associated degradation (ERAD) pathway in mammals. 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