{"id":8011,"date":"2025-10-21T15:07:14","date_gmt":"2025-10-21T15:07:14","guid":{"rendered":"https:\/\/med.virginia.edu\/pharm\/?p=8011"},"modified":"2026-05-22T20:36:54","modified_gmt":"2026-05-22T20:36:54","slug":"bland-lab-has-a-new-paper-published-in-pnas","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/","title":{"rendered":"Bland Lab Has a New Paper Published in PNAS"},"content":{"rendered":"

The Bland Lab has a new paper published in PNAS,<\/em> The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in Drosophila larvae.<\/p>\n

Their results suggest that Dilp6, a hormone produced in response to dietary sugar, may direct the use of sugar for growth instead of fat storage at the end stage of larval development. Their findings reveal different modes of regulation for Dilp2 and Dilp6 and raise the question of how the single known Drosophila<\/i>\u00a0InR integrates divergent signals from distinct Dilps to control growth and metabolism.<\/p>\n

Suzawa M, McPherson WK, Dunham KE, Van Gorder EE, Reddy S, Jamali LA, Bland ML. The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in\u00a0Drosophila<\/i> larvae. Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2426930122. doi: 10.1073\/pnas.2426930122. Epub 2025 Oct 15. PMID: 41091757. The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in Drosophila larvae – PubMed<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Bland Lab has a new paper published in PNAS, The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in Drosophila larvae. Their results suggest that Dilp6, a hormone produced in response to dietary sugar, may direct the use of sugar for growth instead of fat storage at the end […]<\/p>\n","protected":false},"author":2338,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[10],"class_list":["post-8011","post","type-post","status-publish","format-standard","hentry","category-news","tag-intranet"],"acf":false,"yoast_head":"\nBland Lab Has a New Paper Published in PNAS - Department of Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bland Lab Has a New Paper Published in PNAS - Department of Pharmacology\" \/>\n<meta property=\"og:description\" content=\"The Bland Lab has a new paper published in PNAS, The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in Drosophila larvae. Their results suggest that Dilp6, a hormone produced in response to dietary sugar, may direct the use of sugar for growth instead of fat storage at the end […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-21T15:07:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-22T20:36:54+00:00\" \/>\n<meta name=\"author\" content=\"jem5cv@virginia.edu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jem5cv@virginia.edu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/\"},\"author\":{\"name\":\"jem5cv@virginia.edu\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/#\\\/schema\\\/person\\\/9f60b8215e67337a0514e25c8753f627\"},\"headline\":\"Bland Lab Has a New Paper Published in PNAS\",\"datePublished\":\"2025-10-21T15:07:14+00:00\",\"dateModified\":\"2026-05-22T20:36:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/\"},\"wordCount\":166,\"commentCount\":0,\"keywords\":[\"Intranet\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/\",\"name\":\"Bland Lab Has a New Paper Published in PNAS - Department of Pharmacology\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/#website\"},\"datePublished\":\"2025-10-21T15:07:14+00:00\",\"dateModified\":\"2026-05-22T20:36:54+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/#\\\/schema\\\/person\\\/9f60b8215e67337a0514e25c8753f627\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/2025\\\/10\\\/21\\\/bland-lab-has-a-new-paper-published-in-pnas\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Bland Lab Has a New Paper Published in PNAS\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/#website\",\"url\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/\",\"name\":\"Department of Pharmacology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/#\\\/schema\\\/person\\\/9f60b8215e67337a0514e25c8753f627\",\"name\":\"jem5cv@virginia.edu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f9b80084344dd968eb2314c5779524777340100d368c47c1d1db48889dad120d?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f9b80084344dd968eb2314c5779524777340100d368c47c1d1db48889dad120d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f9b80084344dd968eb2314c5779524777340100d368c47c1d1db48889dad120d?s=96&d=mm&r=g\",\"caption\":\"jem5cv@virginia.edu\"},\"url\":\"https:\\\/\\\/med.virginia.edu\\\/pharm\\\/author\\\/jem5cvvirginia-edu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Bland Lab Has a New Paper Published in PNAS - Department of Pharmacology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/","og_locale":"en_US","og_type":"article","og_title":"Bland Lab Has a New Paper Published in PNAS - Department of Pharmacology","og_description":"The Bland Lab has a new paper published in PNAS, The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in Drosophila larvae. Their results suggest that Dilp6, a hormone produced in response to dietary sugar, may direct the use of sugar for growth instead of fat storage at the end […]","og_url":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/","og_site_name":"Department of Pharmacology","article_published_time":"2025-10-21T15:07:14+00:00","article_modified_time":"2026-05-22T20:36:54+00:00","author":"jem5cv@virginia.edu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"jem5cv@virginia.edu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/#article","isPartOf":{"@id":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/"},"author":{"name":"jem5cv@virginia.edu","@id":"https:\/\/med.virginia.edu\/pharm\/#\/schema\/person\/9f60b8215e67337a0514e25c8753f627"},"headline":"Bland Lab Has a New Paper Published in PNAS","datePublished":"2025-10-21T15:07:14+00:00","dateModified":"2026-05-22T20:36:54+00:00","mainEntityOfPage":{"@id":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/"},"wordCount":166,"commentCount":0,"keywords":["Intranet"],"articleSection":["News"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/","url":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/","name":"Bland Lab Has a New Paper Published in PNAS - Department of Pharmacology","isPartOf":{"@id":"https:\/\/med.virginia.edu\/pharm\/#website"},"datePublished":"2025-10-21T15:07:14+00:00","dateModified":"2026-05-22T20:36:54+00:00","author":{"@id":"https:\/\/med.virginia.edu\/pharm\/#\/schema\/person\/9f60b8215e67337a0514e25c8753f627"},"breadcrumb":{"@id":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/med.virginia.edu\/pharm\/2025\/10\/21\/bland-lab-has-a-new-paper-published-in-pnas\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.virginia.edu\/pharm\/"},{"@type":"ListItem","position":2,"name":"Bland Lab Has a New Paper Published in PNAS"}]},{"@type":"WebSite","@id":"https:\/\/med.virginia.edu\/pharm\/#website","url":"https:\/\/med.virginia.edu\/pharm\/","name":"Department of Pharmacology","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.virginia.edu\/pharm\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/med.virginia.edu\/pharm\/#\/schema\/person\/9f60b8215e67337a0514e25c8753f627","name":"jem5cv@virginia.edu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/f9b80084344dd968eb2314c5779524777340100d368c47c1d1db48889dad120d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/f9b80084344dd968eb2314c5779524777340100d368c47c1d1db48889dad120d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f9b80084344dd968eb2314c5779524777340100d368c47c1d1db48889dad120d?s=96&d=mm&r=g","caption":"jem5cv@virginia.edu"},"url":"https:\/\/med.virginia.edu\/pharm\/author\/jem5cvvirginia-edu\/"}]}},"_links":{"self":[{"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/posts\/8011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/users\/2338"}],"replies":[{"embeddable":true,"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/comments?post=8011"}],"version-history":[{"count":2,"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/posts\/8011\/revisions"}],"predecessor-version":[{"id":8013,"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/posts\/8011\/revisions\/8013"}],"wp:attachment":[{"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/media?parent=8011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/categories?post=8011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.virginia.edu\/pharm\/wp-json\/wp\/v2\/tags?post=8011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}