Nolan A. Wages, Ph.D.

Nolan Wages.JPGDr. Wages is an Associate Professor in the Division of Translational Research and Applied Statistics in the Department of Public Health Sciences. As a member of this division, the majority of his research effort is related to cancer research and its applications. Dr. Wages is an active member of the UVA Cancer Center Biostatistics Shared Resource, for which he works with cancer center members on the design and analysis of clinical trials. With funding from a NCI/NIH K25 Mentored Quantitative Research Career Development Award, his current methodological research involves the design and analysis of early-phase clinical trials, with a particular focus on studies of combined immunotherapies.

Associate Professor
Translational Research & Applied Statistics
Ph.D., Statistics, University of Virginia, 2010

P.O. Box 800717
Tel: 1-434-924-8222
Fax: 1-434-243-5787
West Complex Old Med School Room 3890

Research Interests:

  • Design and analysis of early-phase clinical trials in oncology.

Professional Service:

Teaching Responsibilities:

  • PHS 7000 – Biostatistics I, January Term
  • Introduction to Statistics session, Foundations of Medicine

Additional Resources:

Selected Publications:

  1. Wages NA, Portell CA, Williams ME, Conaway MR, Petroni GR (2017). Implementation of a model-based design in a phase 1b study of combined targeted agents. Clinical Cancer Research, in press. NIHMSID: NIHMS892921.
  2. Wages NA, Slingluff CL, Petroni GR (2017). Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies. Annals of Oncology, 28: 696-701. PMID: 28011450.
  3. Conaway MR, Wages NA (2017). Designs for phase I trials in ordered groups. Statistics in Medicine, 36(2): 254-265. PMID: 27624880.
  4. Horton BJ, Wages NA, Conaway MR (2017). Performance of toxicity probability interval based designs in contrast to the continual reassessment method. Statistics in Medicine, 36(2): 291-300. PMID: 27435150.
  5. Petroni GR, Wages NA, Paux G, Dubois F (2017). Implementation of adaptive methods in early-phase clinical trials. Statistics in Medicine, 36(2): 215-224. PMID: 26928191.
  6. Iasonos A, Wages NA, Conaway MR, Cheung YK, Yuan Y, O’Quigley J (2016). Dimension of model parameter space and operating characteristics in adaptive dose-finding studies. Statistics in Medicine, 35(21), 3760-3675. PMCID: PMC4965325
  7. Wages NA, O’Quigley J, Conaway MR (2014). Phase I design for completely or partially ordered treatment schedules. Statistics in Medicine, 33(4): 569-579. PMID: 24114957.
  8. Wages NA, Conaway MR, O’Quigley J (2013). Performance of two-stage continual reassessment method relative to an optimal benchmark. Clinical Trials, 10: 862-75. PMID: 24085776.
  9. Wages NA, Conaway MR, O’Quigley J (2013). Using the time-to-event continual reassessment method in the presence of partial orders. Statistics in Medicine, 32: 131–141. PMID: 22806898.
  10. Wages NA, Conaway MR, O’Quigley J (2011). Continual reassessment method for partial ordering. Biometrics, 67: 1555-1563. PMID: 21361888.

                 Full list of Publications