{"id":529,"date":"2015-10-27T13:49:46","date_gmt":"2015-10-27T17:49:46","guid":{"rendered":"https:\/\/med.virginia.edu\/radiology-research\/?page_id=529"},"modified":"2019-12-05T11:16:45","modified_gmt":"2019-12-05T16:16:45","slug":"john-mugler","status":"publish","type":"page","link":"https:\/\/med.virginia.edu\/radiology-research\/john-mugler\/","title":{"rendered":"John P. Mugler, III, PhD"},"content":{"rendered":"

\"<\/a><\/p>\n

Director of\u00a0Medical Imaging Research
\nProfessor of Radiology and Medical Imaging
\nProfessor of Biomedical Engineering<\/h5>\n

BS, University of Virginia, 1980
\nMS, Stanford University, 1981
\nPhD, Biomedical Engineering, University of Virginia, 1988<\/p>\n

University of Virginia
\nDepartment of Radiology and Medical Imaging Research
\nSnyder Translational Research Building – Room 154
\n480 Ray C. Hunt Dr.
\nCharlottesville, VA\u00a0 22903<\/p>\n

434-982-1674
\nJohn.Mugler@virginia.edu<\/a><\/p>\n

Research Interests<\/h4>\n

My research focuses on the development and optimization of magnetic resonance imaging (MRI) techniques, and draws on a variety of physics and engineering principles with a strong emphasis on theoretical modeling and simulation, and on practical implementation and evaluation.<\/p>\n

Currently, major projects include imaging and spectroscopy of the human lung using hyperpolarized helium- and xenon-based methods, and high-resolution 3-D imaging using conventional proton-based methods.\u00a0 Hyperpolarized helium and xenon are new MR-based gaseous contrast agents that are particularly well suited for imaging air spaces such as those of the lung.\u00a0 Hyperpolarized-gas MR provides high-resolution, detailed images of the lung that are far superior in quality to those from any existing clinical imaging method, and offers a variety of approaches for obtaining unique functional information about the lung.\u00a0 Our research on high-resolution 3-D imaging aims to increase spatial resolution, decrease acquisition time, and improve image quality for methods applicable to routine clinical imaging throughout the human body.<\/p>\n

Research\u00a0Lab<\/h4>\n

Hyperpolarized Gas MR Imaging<\/a><\/p>\n

MRI Technique Development<\/a><\/p>\n

Publications<\/h4>\n
\n

Hyperpolarized xenon-129 gas-exchange imaging of lung microstructure: First case studies in subjects with obstructive lung disease.
\n<\/a>Dregely I, Mugler JP 3rd, Ruset IC, Altes TA, Mata JF, Miller GW, Ketel J. Ketel S, Distelbrink J, Hersman FW. Ruppert K.
\nJ Magn Reson Imaging 2011; 33(5):1052-62.<\/p>\n

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129.<\/a>
\nMugler JP 3rd, Altes TA, Ruset IC, Dregely IM, Mata JF, Miller GW, Ketel S, Ketel J, Hersman FW, Ruppert K.
\nProc Natl Acad Sci U S A. 2010 Dec 14;50:21707-12.<\/p>\n

Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke.<\/a>
\nParmar JP, Rogers WJ, Mugler JP 3rd, Baskurt E, Altes TA, Nandalur KR, Stukenborg GJ, Phillips CD, Hagspiel KD, Matsumoto AH, Dake MD, Kramer CM.
\nCirculation. 2010 Nov 16;20:2031-8.<\/p>\n

A short-breath-hold technique for lung pO2 mapping with 3He MRI.<\/a>
\nMiller GW, Mugler JP 3rd, Altes TA, Cai J, Mata JF, de Lange EE, Tobias WA, Cates GD, Brookeman JR.
\nMagn Reson Med. 2010 Jan;1:127-36.<\/p>\n

Reduction of B1<\/sub> sensitivity in selective single-slab 3D turbo spin echo imaging with very long echo trains.
\n<\/a>Park J, Mugler JP 3rd, Hughes T.
\nMagn Reson Med 2009; 62:1060-66.<\/p>\n<\/div>\n

\n

More Publications<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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