UVA School of Medicine

NICHD P50 Grant

Clinical and Basic Studies in Polycystic Ovary Syndrome (PCOS): NICHD P50 Grant

Clinical Projects

Project I: Testosterone – GnRH Pulse Frequency and the Evolution of PCOS in Adolescence.
PIs: Christopher R. McCartney, MD, and John C. Marshall, MD PhD
(Co-I: Christine Burt Solorzano, MD)

Clinical Pilot Project: Urinary Exosomal DENND1A.V2 as a Predictor of Peripubertal Hyperandogenemia.
PIs: Christopher R. McCartney, MD, and John C. Marshall, MD PhD
(Co-I: Christine Burt Solorzano, MD)

Basic Projects

Project II:   Hypothalamic Steroid Receptors and the Pathogenesis of PCOS
PI: Jon E. Levine, PhD, Director – Wisconsin National Primate Research Center

Project III: Steroid-Metabolic Interactions in the Control of GnRH Neurons.
PI: Suzanne M. Moenter, PhD, University of Michigan

Cores

Administrative Core:  John C. Marshall, MD, PhD, Director-Center for Research in Reproduction

Outreach and Educational Core:  Christine Burt Solorzano, MD

Ligand Assay and Analysis Core:  Daniel J. Haisenleder, PhD