Studies for Women

Polycystic Ovary Syndrome: Studies for Women (18 to 49 years)

 

Investigation of estradiol-induced gonadotropin surge generation in PCOS (IRB-HSR # 19692).

The goal of this study is to learn how a hormone called estradiol (estrogen) affects the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in women with PCOS compared to women without PCOS. We are currently recruiting women ages 18-35 with or without PCOS, with a BMI ≤ 40 kg/m2. Participants must not have taken contraceptive pills or hormonal medications for 3 months prior to the study. This study requires a screening visit that lasts about 1.5 hours, and 8 – 10 morning outpatient visits (8am – 8:30am). Participants will wear estradiol (estrogen) patches throughout the course of the outpatient visits. Participants will collect all of their urine during the study and wear estrogen patches for up to 8 days. Participants will have the option of having a transvaginal ovarian ultrasound. Compensation is up to $425 for completion.

 

Relative contributions of predictors of hyperandrogenism in older vs. young women with PCOS (IRB-HSR# 21723)

The goal of this study is to find out how characteristics of PCOS improve as women with PCOS get older. We are currently recruiting women with PCOS ages 20-30 and 40-49, with a BMI ≤ 40 kg/m2. Participants must not have taken contraceptive pills or hormonal medications for 3 months prior to the study. This study will require 4-5 visits. The 1st (screening) visit would last about 1.5 hours – to make sure you qualify and that it is safe for you to participate. The 2nd visit is to draw blood and perform a transvaginal ultrasound to make sure it is safe to proceed with the overnight admission. The overnight admission to the CRU will last about 15.5 hours (~5pm – 8:30am). The 4th and final outpatient visit will be the morning (7:30am – 11am) after you go home from your overnight admission. You will be asked to take 2 medications if you participate in the study. Compensation for completion is $300.

 

Relative desirability of metformin vs. birth control pill in treating PCOS in women of later reproductive age (IRB-HSR# 21649)

The goal of this study is to see if the medication metformin is as effective as birth control pills in treating women with PCOS who are 40 to 49 years old, with a BMI ≤ 40 kg/m2 Participants must not have taken contraceptive pills or hormonal medications for 3 months prior to the study. This study requires 7 outpatient visits over 12 months. The first screening visit lasts about 1.5 hours, to make sure you qualify for the study and that it is safe for you to participate. Participants will have a transvaginal ultrasound at the 2nd visit. The remaining visits will take 1-3 hours. Participants will take metformin for 6 months and birth control for 6 months. Participants will collect saliva samples at home twice weekly. Compensation for completion is $480.

 

Contact Melissa Gilrain at  pcos@virginia.edu or (434) 243-6911 for more information.