Moore Lab

At Moore Lab, we study the gastrointestinal (GI) tract, the largest tissue interface of humans with their environment. The GI tract absorbs energy from food for growth and sustenance, and partners with—or defends against—trillions of gut microbes.

Specifically, we study the structure and function of the GI tract during childhood. We aim to make discoveries surrounding nutrition, growth, immunity, and host-microbe interactions.


Sean Moore, MD and Jason Papin, PhD, Discover How Microbes in Our Guts Regulate the Body’s Biological Clock

A new discovery from the University of Virginia School of Medicine about how the microbes in our guts regulate the body’s biological clock could help us battle sleep disorders, combat jet lag, fight off foodborne illness and even improve chemotherapy outcomes.

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a group of people stand in front of the UVA rotunda with a gold plaque and green liquid.

The Moore Lab becomes GOLD Green Lab Certified

We are thrilled to announce that this past year the Moore Lab became a certified Green Lab and was awarded with a gold medal, the highest level for this certification. This recognition resulted from a series of actions implemented by team Moore Lab to reduce the scientific research footprint and became a more sustainable place.

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Moore Laboratory Awarded Grant from The Jefferson Trust

Moore Laboratory Awarded $100,000 Grant from The Jefferson Trust, to create a novel instrument to detect bioluminescence in organ-on-a-chip

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A cartoon of the intestine with small bacteria and signaling molecules.

UVA Researchers: Body Controls Replacement of Cells that Line Gut

Researchers say that a discovery could let doctors figure out when to give certain treatments and vaccines for best effect in patients.

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Moore Lab Attends the Freston Conference in Washington, D.C. in October

After many months of safety precautions due to COVID-19, the Gastroenterology and related organoid community reassembled in early October at the Freston Conference, hosted at the Madison Hotel in wonderful…

Moore Lab Contributes to UVA Winning Top Academic Organization Award for the 2022 International Freezer Challenge

Sean Moore, MD, professor and principal research investigator in the Department of Pediatrics, Child Health Research Center, and his lab’s participation in the 2022 Freezer Challenge contributed to the University…

Med Students Present at the Medical Student Research Symposium

This week Jesse Zhao and Michelle Yeghyayan, medical students who worked with us in the lab over the summer, presented their work at the Medical Student Research Symposium at UVA.…

Mini-Medical School at the Moore Lab – 10/3/18

  Our lab had the exciting opportunity to host members of the Charlottesville/Albemarle community for a visit to the lab as part of the Mini-Medical School here at the University…

Moore lab sweeps DDW

2018 Digestive Disease Week in Washington, D.C. was a great success this year! DDW is the largest and most prestigious meeting in the world for the GI professional. Every year…