Moore Lab

At Moore Lab, we study the gastrointestinal (GI) tract, the largest tissue interface of humans with their environment. The GI tract absorbs energy from food for growth and sustenance, and partners with—or defends against—trillions of gut microbes.

Specifically, we study the structure and function of the GI tract during childhood. We aim to make discoveries surrounding nutrition, growth, immunity, and host-microbe interactions.


Sean Moore, MD and Jason Papin, PhD, Discover How Microbes in Our Guts Regulate the Body’s Biological Clock

A new discovery from the University of Virginia School of Medicine about how the microbes in our guts regulate the body’s biological clock could help us battle sleep disorders, combat jet lag, fight off foodborne illness and even improve chemotherapy outcomes.

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Research Trainee Competition placement

We are proud to announce Dr. Ajay Kumar’s successful placement of the Research Trainee Competition.

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Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

The molecular paper recommended by the F1000 faculty as being of special significance in its field.

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UVA Researchers: Body Controls Replacement of Cells that Line Gut

Researchers say that a discovery could let doctors figure out when to give certain treatments and vaccines for best effect in patients.

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Moore Lab Attends the Freston Conference in Washington, D.C. in October

After many months of safety precautions due to COVID-19, the Gastroenterology and related organoid community reassembled in early October at the Freston Conference, hosted at the Madison Hotel in wonderful…

Moore Lab Contributes to UVA Winning Top Academic Organization Award for the 2022 International Freezer Challenge

Sean Moore, MD, professor and principal research investigator in the Department of Pediatrics, Child Health Research Center, and his lab’s participation in the 2022 Freezer Challenge contributed to the University…

Med Students Present at the Medical Student Research Symposium

This week Jesse Zhao and Michelle Yeghyayan, medical students who worked with us in the lab over the summer, presented their work at the Medical Student Research Symposium at UVA.…

Mini-Medical School at the Moore Lab – 10/3/18

  Our lab had the exciting opportunity to host members of the Charlottesville/Albemarle community for a visit to the lab as part of the Mini-Medical School here at the University…

Moore lab sweeps DDW

2018 Digestive Disease Week in Washington, D.C. was a great success this year! DDW is the largest and most prestigious meeting in the world for the GI professional. Every year…


Bacteria from our gut damage DNA in unexpected ways in #IBD and #CRC: Brilliant paper by Noah Palm and colleagues out in @ScienceMagazine today
Our accompanying perspective on this landmark study + genotoxic bugs with @DrCindySears:

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