Sheynkman Lab

Laboratory of Proteoform Medicine

At the Sheynkman Lab, we study disease-relevant protein forms, or “proteoforms,” by integrating cutting-edge analytical and computational approaches from genomics, proteomics, and systems biology. This precision medicine approach is applied in a disease agnostic manner to elucidate proteoform-driven rewiring events in cardiovascular disease, neurological disorders, and cancer.

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Gloria Sheynkman, PhD: Meet the Scientist Mapping a Million Proteoforms to Fight Disease

Sheynkman Lab Mission

At the Sheynkman Lab, we are working to found a new area of the “Disease Proteoform Systems Biology”, which is a systems biology approach to discover disease-driving “proteoforms” for therapeutic intervention. To accomplish this, we are integrating a unique set of cutting-edge analytical and computational approaches from human disease genetics, genomics, proteomics, and systems and network biology.

Research Goals

To understand how human proteomic variation underlies phenotypic variation

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Approaches

Long Read Transcriptomics Technologies "Precision" Proteogenomics to characterize protein isoforms Functional proteomics- Screening for driver proteoforms

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Applications to Disease

We apply our research to a variety of disease communities, including coronary artery disease (CAD), osteoporosis (BMD), chronic obstructive pulmonary disease (COPD), cancer, and the study of acute myeloid leukemia (AML).

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