Patrick Seelheim, Ph.D.

Patrick Seelheim, Ph.D.
Research Associate
Email: ps9hd@Virginia.EDU

Patrick Seelheim was born in Wuppertal, Germany. He studied Chemistry with focus on physical chemistry and biochemistry at the University of Münster, Germany and the University of California, Santa Barbara, CA.  In 2013, he earned his PhD in biochemistry from the University of Münster where he investigated the human ABC transporter MRP3. After a joint university-industry project on biochip-based translocation assays, he came to the University of Virginia in 2014 to work on bacterial outer-membrane proteins.


Kreutzberger AJB, Kiessling V, Liang B, Seelheim P, Jakhanwal S, Jahn R, Castle JD, Tamm LK. Reconstitution of calcium-mediated exocytosis of dense-core vesicles. Science Advances 19 Jul 2017: Vol. 3. No. 7. E1603208 DOI:10.1126/sciadv.1603208 (

Kucharska, I.,  Seelheim, P., Edrington, T.,  Liang,  B., Tamm, L.K.  OprG Harnesses the Dynamics of its Extracellular Loops to Transport Small Amino Acids across the Outer Membrane of Pseudomonas aeruginosa  Structure December, 2015, 23:2234-2245. (

M. Urban, A. Kleefen, N. Mukherjee, P. Seelheim, B. Windschiegl, M. Vor der Bruggen, A. Koçer & R. Tampé (2014), “Highly Parallel Transport Recordings on a Membrane-on-Nanopore Chip at Single Molecule Resolution”, Nano Letters 14(3), 1674–1680.

O. Roling, C. Wendeln, U. Kauscher, P. Seelheim, H. J. Galla & B. J. Ravoo (2013), “Layer-by-Layer Deposition of Vesicles Mediated by Supramolecular Interactions”, Langmuir 29(32), 10174–10182.

K. Duning, D. O. Wennmann, A. Bokemeyer, C. Reissner, H. Wersching, C. Thomas, J. Buschert, K. Guske, V. Franzke, A. Floel, H. Lohmann, S. Knecht, S. M. Brand, M. Poter, U. Rescher, M. Missler, P. Seelheim, C. Propper, T. M. Boeckers, L. Makuch, R. Huganir, T. Weide, E. Brand, H. Pavenstadt & J. Kremerskothen (2013), “Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance”, Translational Psychiatry 3, e272.

Seelheim & H.-J. Galla (2013), “Tethered proteoliposomes containing human ABC transporter MRP3: New perspectives for biosensor application based on transmembrane proteins”, Biochemical and Biophysical Research Communications 431(3), 519–523.

Seelheim, A. Wüllner & H.-J. Galla (2013), “Substrate translocation and stimulated ATP hydrolysis of human ABC transporter MRP3 show positive cooperativity and are half-coupled”, Biophysical Chemistry 171, 31–37.

J. J. Weigand, N. Burford, R. J. Davidson, S. Cameron & P. Seelheim (2009), “New Synthetic Procedures to Catena-Phosphorus Cations: Preparation and Dissociation of the First cyclo-Phosphino-halophosphonium Salts”, Journal of the American Chemical Society 131(49), 17943–17953.