Sung-Tae Yang, Ph.D.

Sung-Tae Yang, Ph.D.
Research Associate
Email: sy3v@Virginia.EDU

Hometown: Namwon, South Korea

Ph.D.: Gwangju Institute of Science and Technology, 2006, South Korea

B.S.: Yonsei University, 2000, South Korea

2006-2007 Postdoctoral Fellow, School of Life Science, GIST, Gwangju, South Korea
2007-2012 Visiting Fellow, National Institute of Child Health & Human Development, Bethesda, MD, USA
2012- Research Associate, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA

Other Experience and Professional Memberships
2005-2006 Member, Korean Peptide Protein Society
2011 Member, American Biophysical Society

Honors
1998 Award of honor student, Yonsei University, South Korea
2000-2006 Brain Korea 21 Scholarship, GIST, South Korea

Publications:

Selected Peer-reviewed Publications (in reverse chronological order)

18. Yang ST, Kreutzberger AJB, Kiessling V, Ganser-Pornillos BK, White JM, Tamm LK. (2017) HIV virions sense plasma membrane heterogeneity for cell entry. Sci. Adv. Jun 2017: Vol. 3, no. 6, e1700338(http://advances.sciencemag.org/content/3/6/e1700338)

17. Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion. Yang ST, Kiessling V, Tamm LK Nat Commun. 2016 Apr 26;7:11401. (http://www.ncbi.nlm.nih.gov/pubmed/27113279)

16. Supported lipid bilayers as models for studying membrane domains. Kiessling V, Yang ST, Tamm LK. Curr Top Membr. 2015;75:1-23. doi: 10.1016/bs.ctm.2015.03.001. Epub 2015 Apr 11. (http://www.ncbi.nlm.nih.gov/pubmed/26015279 )

15. HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains.
Yang ST, Kiessling V, Simmons JA, White JM, Tamm LK. Nat Chem Biol. 2015 Jun;11(6):424-31. doi: 10.1038/nchembio.1800. Epub 2015 Apr 27. (http://www.ncbi.nlm.nih.gov/pubmed/25915200)

14. Yang, S.T., Zaitseva, E., Chernomordik, L.V. & Melikov, K. (2010) Cell-penetrating Peptide induces leaky
fusion of liposomes containing late endosome-specific anionic lipid. Biophysical Journal 99, 2525-2533,
PMC2955498.

13. Zaitseva, E., Yang, S.T., Melikov, K., Pourmal, S., & Chernomordik, L.V. (2010) Dengue virus ensures its
fusion in late endosomes using compartment-specific lipids. PLoS Pathogens 6, e1001131, PMC2951369.

12. Abes, R., Moulton, H.M., Clair, P., Yang, S.T., Abes, S., Melikov, K., Prevot, P., Youngblood, D.S., Iversen,
P.L., Chernomordik, L.V., & Lebleu, B. (2008) Delivery of steric block morpholino oligomers by (R-X-R)4
peptides: structure-activity studies. Nucleic Acids Research 36, 6343-6354, PMC2582615.

11. Lee, J.Y., Yang, S.T., Lee, S.K., Jung, H.H., Shin, S.Y., Hahm, K.S., & Kim, J.I. (2008) Salt-resistant
homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide. FEBS Journal 275, 3911-3920, Not
NIH funded.

10. Zhu, W.L., Song, Y.M., Park, Y., Park, K.H., Yang, S.T., Kim, J.I., Park, I.S., Hahm, K.S., & Shin, S.Y.
(2007) Substitution of the leucine zipper sequence in melittin with peptoid residues affects self-association,
cell selectivity, and mode of action. Biochimica et Biophysica Acta – Biomembranes 1768, 1506-1517.

9. Choi, J., Kim, J., Kim, K., Yang, S.T., Kim, J.I., & Jon, S. (2007) A rationally designed macrocyclic cavitand
that kills bacteria with high efficacy and good selectivity. Chemical Communication 11, 1151-1153.

8. Yang, S.T., Shin, S.Y., & Kim, J.I. (2007) Interaction mode of a symmetric Trp-rich undeca peptide PST11-
RK with lipid bilayers. FEBS Letters 581, 157-163.

7. Yang, S.T., Lee, J.Y., Kim, H.J., Eu, Y.J., Shin, S.Y., Hahm, K.S., & Kim, J.I. (2006) Contribution of a
central proline in model amphipathic alpha-helical peptides to self-association, interaction with
phospholipids, and antimicrobial mode of action. FEBS Journal 273, 4040-4054.

6. Yang, S.T., Shin, S.Y., Hahm, K.S., & Kim, J.I. (2006) Different modes in antibiotic action of tritrpticin
analogs, cathelicidin-derived Trp-rich and Pro/Arg-rich peptides. Biochimica et Biophysica Acta –
Biomembranes 1758, 1580-1586.

5. Yang, S.T., Shin, S.Y., Hahm, K.S., & Kim, J.I. (2006) Design of perfectly symmetric Trp-rich peptides with
potent and broad spectrum antimicrobial activity. International Journal of Antimicrobial Agents 27, 325-330.

4. Yang, S.T., Jeon, J.H., Kim, Y., Shin, S.Y., Hahm, K.S., & Kim, J.I. (2006) Possible role of a PXXP central
hinge on antibacterial activity and membrane interaction of PMAP-23, a member of cathelicidin family.
Biochemistry 45, 1775-1784.

3. Song, Y.M., Park, Y., Lim, S.S., Yang, S.T., Woo, E.R., Park, I.S., Lee, J.S., Kim, J.I., Hahm, K.S., Kim, Y.,
& Shin, S.Y. (2005) Cell selectivity and mechanism of action of antimicrobial model peptides containing
peptoid residues. Biochemistry 44, 12094-12106.

2. Yang, S.T., Shin, S.Y., Lee, C.W., Kim, Y.C., Hahm, K.S., & Kim, J.I. (2003) Selective cytotoxicity following
Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure. FEBS Letters 540, 229-
233.

1. Yang, S.T., Shin, S.Y., Kim, Y.C., Kim, Y., Hahm, K.S., & Kim, J.I. (2002) Conformation-dependent
antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide. Biochemical and Biophysical
Research Communications 296, 1044-1050.