{"id":441,"date":"2015-05-01T14:22:49","date_gmt":"2015-05-01T18:22:49","guid":{"rendered":"http:\/\/med.virginia.edu\/tamm-lab\/?p=441"},"modified":"2017-03-30T13:23:50","modified_gmt":"2017-03-30T17:23:50","slug":"congratulations-sung-tae-volker-et-al-for-the-article-in-nature-chemical-biology","status":"publish","type":"post","link":"https:\/\/med.virginia.edu\/tamm-lab\/congratulations-sung-tae-volker-et-al-for-the-article-in-nature-chemical-biology\/","title":{"rendered":"Congratulations Sung-Tae, Volker, et al for the article in Nature Chemical Biology"},"content":{"rendered":"<p>&nbsp;<\/p>\n<h3>HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains<\/h3>\n<p>Sung-Tae Yang, Volker Kiessling, James A. Simmons, Judith M. White, &amp; Lukas K. Tamm<\/p>\n<p>Published online: 21 April 2015<\/p>\n<p>DOI: 10.1038\/NCHEMBIO.1800<\/p>\n<p>&nbsp;<\/p>\n<p>Lipid rafts in plasma membranes have emerged as possible platforms for the entry of HIV and other viruses into cells. However, little is known about how lipid phase heterogeneity contributes to viral entry because of the fine-grained and still poorly understood complexity of biological membranes. We used model systems mimicking HIV envelopes and T cell membranes and found that raft-like liquid-ordered (Lo-phase) lipid domains were necessary and sufficient for efficient membrane targeting and fusion. Interestingly, membrane binding and fusion were low in homogeneous liquid-disordered (Ld-phase) and Lo-phase membranes, indicating that lipid phase heterogeneity is essential. The HIV fusion peptide preferentially targeted to Lo-Ld boundary regions and promoted full fusion at the interface between ordered and disordered lipids. Ld-phase vesicles proceeded only to hemifusion. Thus, we propose that edges but not areas of raft-like ordered lipid domains are vital for HIV entry and membrane fusion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains Sung-Tae Yang, Volker Kiessling, James A. Simmons, Judith M. White, &amp; Lukas K. Tamm Published online: 21 April 2015 DOI: 10.1038\/NCHEMBIO.1800 &nbsp; Lipid rafts in plasma membranes have emerged as possible platforms for the entry of HIV and other viruses into cells. However, [&hellip;]<\/p>\n","protected":false},"author":431,"featured_media":442,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":false,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Congratulations Sung-Tae, Volker, et al for the article in Nature Chemical Biology - Tamm Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.virginia.edu\/tamm-lab\/congratulations-sung-tae-volker-et-al-for-the-article-in-nature-chemical-biology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Congratulations Sung-Tae, Volker, et al for the article in Nature Chemical Biology - Tamm Lab\" \/>\n<meta property=\"og:description\" content=\"&nbsp; HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains Sung-Tae Yang, Volker Kiessling, James A. 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