Biochemistry

The Ubiquitin System and Human Cancer

Basic and translational brain tumor research

Molecular Biosensors; Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

Biophysics of membrane pore formation; research and therapeutic applications of lipid nanoparticles.

Synthetic biology and protein engineering approaches to develop models of biochemical/biological processes

Developing Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) techniques as a tool for basic biomedical research.

Genome instability syndromes in cancer and immune deficiencies

Protein phosphatases

Hematology and Oncology, Cell Biology, Lipid Signaling, Cancer Cell Signaling, and RNA Biology

Biophysical Chemistry: Membrane protein structure, function, and dynamics

Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging

Structure and Function of Macromolecular Complexes Using Electron Microscopy

Cancer systems biology, Single-cell quantitative biology, Computational modeling

Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

Impact of APOE and lipid metabolism on cell function in Alzheimer's disease.

Basement Membrane Structure and Metalloproteinases

Molecular basis of ciliopathies; Signaling mechanisms of cilia-associated kinases

RNA-protein interactions in antiviral immunity and autoimmune diseases.

Exploring new therapeutics avenues to treat Multiple Sclerosis.

Signal transduction in cancer cells

Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

Molecular Mechanics of Muscle Contraction and Cell Movement

Molecular mechanisms controlling insulin signaling and fat synthesis.

Hematology & Oncology

Mechanisms by which cells direct and regulate protein targeting to the ER and mitochondria, and how molecular control of cell dormancy impacts health and disease.

Metabolic and Genetic Regulation of Aging, Redox Biology, DNA Repair, Comparative and Functional Genomics, Stress Resistance, Drug Discovery, Evolutionary Biology, Synthetic and Systems Biology for Evolutionary Engineering, Adaptive Evolution, Mitochondrial Signaling, Neurodegenerative Diseases

Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

Molecular and metabolic adaptations of cancer cells.

Composition, Biophysics and Physiology of Cellular Membranes

Genetic and Epigenetic stability in human cancer

Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure

Chemical biology of sphingosine 1-phosphate

Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis

Transcriptional Regulation by NFKB

Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers

Chemistry

Regulation and function of tyrosine phosphorylation in complex networks

Obesity and Aging

Systems biology, infectious disease, cancer, toxicology, metabolic engineering

Mechanisms of tissue/organ homeostasis and tumorigeensis

Nuclear Transport, Signaling, and Cancer

Director of Graduate Studies for Microbiology, Immunology and Cancer Biology

Microbial Pathogenesis

Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation

Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

Auditory Neurobiology

Transcriptional Silencing and Aging in Yeast

Gram-positive pathogenesis; type VII secretion; impact of secreted effectors on host-pathogen interactions and immune responses

Spatial Cell Biology. Neuronal Morphogenesis and Disease. Cancer Migration and Invasion.

Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

Prokaryotic immune systems, bacteriophage virology, programmed cell death, pore-forming proteins, evolution of immunity, cGAS-STING, protein engineering

Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

Complex Genome Rearrangements

Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases

Membrane-transport physiology and biophysics

Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery

Clonal hematopoiesis: A new mechanism of cardiovascular disease

Genome instability in cancer and repeat expansion diseases

Mechanisms of DNA repair in chromatin

The formation, function, coordination, and pathology of multinucleated cell types that make up the placenta and musculoskeletal system.

Regulation of miRNA Processing and Function During Oogenesis and Embryogenesis

Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

Molecular Imaging; Cancer Immunology; Vaccines.

Structural biology, Cryo-EM, Mitochondrial stress, Integrated stress response, De novo protein design, Drug development, Neurodegeneration, Heart disease, Cancer

Mechanisms of Huntington's Disease Pathogenesis

Integrating high-throughput proteomic, chemical, genetic and computational tools for target identification and drug discovery in cancer biology

MD-RONC Radiation Oncology

Genetics, Functional Genomics, Epigenetics, Lung repair/regeneration, Metabolic regulation, Alveolar stem cells, Chromatin interaction, Innate immune response, Live-cell imaging

Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.

Single Cell Analysis