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Stefanie Redemann

Stefanie Redemann

Associate Professor, Molecular Physiology and Biological Physics

Primary Location
480 Ray C. Hunt Drive
Charlottesville, Va 22903
Primary Phone Number
434.243.1413
Email
[email protected]
Website
https://med.virginia.edu/redemann-lab/

Bio & Overview

All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in this process have severe implications for development, health and survival of the organism. One major outcome of chromosome segregation errors in mitosis is tumor initiation and progression. Analysis of cancer cell karyotypes revealed that aneuploidy, an abnormal number of chromosomes, is an extremely common feature, with 70 – 95% of cancers from the most commonly affected organs being aneuploid. Aneuploidy is associated with poor patient prognosis, metastasis, and resistance to chemotherapeutics. Chromosome segregation errors during meiosis, are the leading cause of early pregnancy loss and infertility. Our aim is to understand the key molecular and mechanical principles and mechanisms of spindle assembly and chromosome segregation in meiosis and mitosis. We address this by using a combination of cutting-edge imaging technologies, such as large-scale 3D electron tomography and spinning disc live-cell microscopy, as well CRISPR and other genetic tools in tissue culture cells, mouse Oocytes and C. elegans embryos. For more information about Dr. Redemann: https://journals.biologists.com/jcs/article/134/23/jcs259556/273552/Cell-scientist-to-watch-Stefanie-Redemann

Academic Information

Department
Molecular Physiology and Biological Physics
Academic Title
Assistant Professor

Primary Education

  • Diploma, Biology, Technische Universität Darmstadt, 2005
  • PhD, Cell Biology, Max Planck Institute for Cell Biology and Genetics, 2009
  • Post Doc, Cell Biology/ Biophysics, Technische Universität Dresden, Medical Theoretical Center, 2017

Other Affiliations

  • BIMS
  • BIMS

Research Interests

Chromosome segregation and aneuploidy in meiosis and mitosis

Research Disciplines

  • Biology
  • Biophysics
  • Biophysics & Structural Biology
  • Cancer Biology
  • Cell and Developmental Biology
  • Molecular Biology
  • Molecular Physiology and Biological Physics
  • Physiology
  • Structural Biology

Research Opportunities

  • Biophysics & Structural Biology
  • Cancer Biology
  • Cell Biology
  • Chemistry and Physics of Living Systems
  • Molecular Biology
  • Physiological Basis of Human Disease

PhD Programs

  • Biophysics
  • Cell Biology
  • Pharmacology
  • Physiology

Selected Publications

2024

Gong, T., McNally, K. L., Konanoor, S., Peraza, A., Bailey, C., Redemann, S., & McNally, F. J. (2024). Roles of Tubulin Concentration during Prometaphase and Ran-GTP during Anaphase of Caenorhabditis elegans Meiosis. LIFE SCIENCE ALLIANCE, 7(9), 1-17. doi:10.26508/lsa.202402884

Mulligan, R. J., Magaj, M. M., Digilio, L., Redemann, S., Yap, C. C., & Winckler, B. (2024). Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and RILP. JOURNAL OF CELL SCIENCE, 137(9). doi:10.1242/jcs.261765

Zhao, X. -Y., Lempke, S. L., Arroyo, J. C. U., Brown, I. G., Yin, B., Magaj, M. M., . . . Ewald, S. E. (2024). iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse. NATURE COMMUNICATIONS, 15(1). doi:10.1038/s41467-024-46790-y

Zimyanin, V., & Redemann, S. (2024). Microtubule length correlates with spindle length in C. elegans meiosis. CYTOSKELETON. doi:10.1002/cm.21849

Wolpe, A. G., Luse, M. A., Baryiames, C., Schug, W. J., Wolpe, J. B., Johnstone, S. R., . . . Isakson, B. E. (2024). Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress. SCIENCE SIGNALING, 17(821). doi:10.1126/scisignal.adg2622

Niedzialkowska, E., Truong, T. M., Eldredge, L. A., Ali, A., Redemann, S., & Stukenberg, P. T. (2024). Chromosomal passenger complex condensates generate parallel microtubule bundles in vitro.. The Journal of biological chemistry, 300(3), 105669. doi:10.1016/j.jbc.2024.105669

2023

Zimyanin, V., Magaj, M., Yu, C. -H., Gibney, T., Mustafa, B., Horton, X., . . . Redemann, S. (2023). Lack of chromokinesin Klp-19 creates a more rigid midzone and affects force transmission during anaphase in C. elegans.. bioRxiv. doi:10.1101/2023.10.26.564275

Chen, Y. -Z., Zimyanin, V., & Redemann, S. (2023). Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events. LIFE SCIENCE ALLIANCE, 6(11). doi:10.26508/lsa.202302011

Zimyanin, V. L., Pielka, A. -M., Glass, H., Japtok, J., Grossmann, D., Martin, M., . . . Hermann, A. (2023). Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. CELLS, 12(10). doi:10.3390/cells12101352

Lantzsch, I., Yu, C. -H., Chen, Y. -Z., Zimyanin, V., Yazdkhasti, H., Lindow, N., . . . Redemann, S. (2023). Microtubule reorganization during female meiosis in C. elegans (vol 10, e58903, 2021). ELIFE, 12. doi:10.7554/eLife.86893

Chen, Y. -Z., Zimyanin, V., & Redemann, S. (2023). Mitotic events depend on regulation of PLK-1 levels by the mitochondrial protein SPD-3. doi:10.1101/2023.01.11.523633

2022

Mauro, M. S., Celma, G., Zimyanin, V., Magaj, M. M., Gibson, K. H., Redemann, S., & Bahmanyar, S. (2022). Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth. ELIFE, 11. doi:10.7554/eLife.75513

Wolpe, A. G., Luse, M. A., Johnstone, S. R., Xue, J., Sabapathy, V., Wakefield, B., . . . Isakson, B. E. (2022). Endothelial Pannexin 3-B Cell Lymphoma-6 Interactions Protect Against Oxidative Stress. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R5405

2021

Lindow, N., Bruenig, F. N., Dercksen, V. J., Fabig, G., Kiewisz, R., Redemann, S., . . . Baum, D. (2021). Semi-automatic stitching of filamentous structures in image stacks from serial-section electron tomography. JOURNAL OF MICROSCOPY, 284(1), 25-44. doi:10.1111/jmi.13039

Lantzsch, I., Yu, C. -H., Chen, Y. -Z., Zimyanin, V., Yazdkhasti, H., Lindow, N., . . . Redemann, S. (2021). Microtubule reorganization during female meiosis in C. elegans. ELIFE, 10. doi:10.7554/eLife.58903

Palfy, M., & Redemann, S. (2021). Cell scientist to watch - Stefanie Redemann. JOURNAL OF CELL SCIENCE, 134(23). doi:10.1242/jcs.259556

Nian, S., Fan, Z., Freychet, G., Zhernenkov, M., Redemann, S., & Cai, L. -H. (2021). Self-Assembly of Flexible Linear-Semiflexible Bottlebrush-Flexible Linear Triblock Copolymers. MACROMOLECULES, 54(20), 9361-9371. doi:10.1021/acs.macromol.1c01911

2020

Nazockdast, E., & Redemann, S. (2020). Mechanics of the spindle apparatus. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 107, 91-102. doi:10.1016/j.semcdb.2020.06.018

Shimamoto, Y., Redemann, S., & Needleman, D. (2020). Editorial: Mechanics of Cell Division. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8. doi:10.3389/fcell.2020.620111

2019

Baumgart, J., Kirchner, M., Redemann, S., Bond, A., Woodruff, J., Verbavatz, J. -M., . . . Brugues, J. (2019). Soluble tubulin is significantly enriched at mitotic centrosomes. JOURNAL OF CELL BIOLOGY, 218(12), 3977-3985. doi:10.1083/jcb.201902069

Yu, C. -H., Redemann, S., Wu, H. -Y., Kiewisz, R., Yoo, T. Y., Conway, W., . . . Needleman, D. (2019). Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B. MOLECULAR BIOLOGY OF THE CELL, 30(19), 2503-2514. doi:10.1091/mbc.E19-01-0074

Redemann, S., Furthauer, S., Shelley, M., & Mueller-Reichert, T. (2019). Current approaches for the analysis of spindle organization. CURRENT OPINION IN STRUCTURAL BIOLOGY, 58, 269-277. doi:10.1016/j.sbi.2019.05.023

2018

Zwicker, D., Baumgart, J., Redemann, S., Mueller-Reichert, T., Hyman, A. A., & Juelicher, F. (2018). Positioning of Particles in Active Droplets. PHYSICAL REVIEW LETTERS, 121(15). doi:10.1103/PhysRevLett.121.158102

Chaaban, S., Jariwala, S., Hsu, C. -T., Redemann, S., Kollman, J. M., Mueller-Reichert, T., . . . Brouhard, G. J. (2018). The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth. DEVELOPMENTAL CELL, 47(2), 191-+. doi:10.1016/j.devcel.2018.08.023

Redemann, S., Lantzsch, I., Lindow, N., Prohaska, S., Srayko, M., & Mueller-Reichert, T. (2018). A Switch in Microtubule Orientation during C. elegans Meiosis. CURRENT BIOLOGY, 28(18), 2991-+. doi:10.1016/j.cub.2018.07.012

Mueller-Reichert, T., Kiewisz, R., & Redemann, S. (2018). Mitotic spindles revisited - new insights from 3D electron microscopy. JOURNAL OF CELL SCIENCE, 131(3). doi:10.1242/jcs.211383

Lindow, N., Redemann, S., Bruenig, F., Fabig, G., Mueller-Reichert, T., & Prohaska, S. (2018). Quantification of three-dimensional spindle architecture. MITOSIS AND MEIOSIS, PT B, 145, 45-64. doi:10.1016/bs.mcb.2018.03.012

2017

Redemann, S., Baumgart, J., Lindow, N., Shelley, M., Nazockdast, E., Kratz, A., . . . Mueller-Reichert, T. (2017). C. elegans chromosomes connect to centrosomes by anchoring into the spindle network. NATURE COMMUNICATIONS, 8. doi:10.1038/ncomms15288

2016

Pecreaux, J., Redemann, S., Alayan, Z., Mercat, B., Pastezeur, S., Garzon-Coral, C., . . . Howard, J. (2016). The Mitotic spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability. BIOPHYSICAL JOURNAL, 111(8), 1773-1784. doi:10.1016/j.bpj.2016.09.007

2014

Redemann, S., Weber, B., Moeller, M., Verbavatz, J. -M., Hyman, A. A., Baum, D., . . . Mueller-Reichert, T. (2014). The Segmentation of Microtubules in Electron Tomograms Using Amira. MITOSIS: METHODS AND PROTOCOLS, 1136, 261-278. doi:10.1007/978-1-4939-0329-0_12

2013

Redemann, S., & Mueller-Reichert, T. (2013). Correlative light and electron microscopy for the analysis of cell division. JOURNAL OF MICROSCOPY, 251(2), 109-112. doi:10.1111/jmi.12056

2011

Redemann, S., Schloissnig, S., Ernst, S., Pozniakowsky, A., Ayloo, S., Hyman, A. A., & Bringmann, H. (2011). Codon adaptation-based control of protein expression in C. elegans. NATURE METHODS, 8(3), 250-252. doi:10.1038/NMETH.1565

2010

Redemann, S., Pecreaux, J., Goehring, N. W., Khairy, K., Stelzer, E. H. K., Hyman, A. A., & Howard, J. (2010). Membrane Invaginations Reveal Cortical Sites that Pull on Mitotic Spindles in One-Cell C. elegans Embryos. PLOS ONE, 5(8). doi:10.1371/journal.pone.0012301

Lambert, M. N., Voecker, E., Blumberg, S., Redemann, S., Gajraj, A., Meiners, J. -C., & Walter, N. G. (2010). Mg2+-induced compaction of single RNA molecules monitored by tethered particle microscopy (vol 90, pg 3672, 2006). BIOPHYSICAL JOURNAL, 98(9), 2041. doi:10.1016/j.bpj.2010.04.020