Research
Research programs in UVA's Division of Infectious Diseases & International Health and related disciplines are supported by more than $29 million in extramural funding. Faculty members conduct bench and clinical research of national and international significance, including the development of vaccines, diagnostic tools, and treatments for a variety of infectious diseases.
The division’s international and global research partnerships are one of its strengths. UVA faculty work collaboratively with university-based colleagues in many countries, with major partnerships at sites in Bangladesh, Brazil, Haiti, India, Pakistan, South Africa, Tanzania and Uganda.
To learn more about a specific ID faculty member's research, go to the School of Medicine Research Faculty Directory and search by the individual's last name.
Research Affinity Group in the Department or Affiliated Centers
Infectious Diseases
Interest Group: HIV and related syndemics
Focus: HIV, access to care and medications, health policy, social determinants of health; interested in expanding into HIV and (1) cardiovascular disease, (2) metabolic syndrome, and (3) aging
Meetings: ad hoc
Location: Zoom
Contact: Kate McManus ([email protected])
Center for Immunology Research
Interest Group: CIC Café (faculty only group)
Focus: invite people to do brainstorming around a topic, grant application feedback
Meetings: twice a month, first and third Tuesday (except special meetings), 3:00 – 4:00 PM
Location: MR6 Room 3526
Contact: Jie Sun ([email protected])
Our Division's Research Activities:
Interdisciplinary Research Opportunities:
Epidemiology & Clinical Infectious Diseases
Research in epidemiology and clinical infectious diseases is conducted at UVA's hospital and medical center and at ID partner sites overseas, in areas that include antibiotic resistance (its spread and control), diagnostics, epidemiology of infectious diseases within both patient and general populations, and factors that influence disease susceptibility.
The following division faculty conduct research and instruct fellows in Clinical Infectious Diseases:
Multidrug resistant tuberculosis (MDR-TB); pharmacokinetics; clinical application of diagnostics for TB; clinical trials to optimize TB treatment; chronic illness/ TB integration
Scott K. Heysell
Multidrug resistant tuberculosis (MDR-TB); pharmacokinetics; clinical application of diagnostics for TB; clinical trials to optimize TB treatment; chronic illness/ TB integration
Molecular diagnostics, Tuberculosis, Global Health
Eric R. Houpt
Molecular diagnostics, Tuberculosis, Global Health
Using immune biomarkers to predict outcomes of C. difficile infection
Gregory R. Madden
Using immune biomarkers to predict outcomes of C. difficile infection
Molecular epidemiology of multidrug resistant gram negative bacilli, laboratory detection of gram negative antibiotic resistance, prevention of acquisition of resistant bacterial pathogens and treatment of multi-drug resistant gram negative bacteria.
Amy J. Mathers
Molecular epidemiology of multidrug resistant gram negative bacilli, laboratory detection of gram negative antibiotic resistance, prevention of acquisition of resistant bacterial pathogens and treatment of multi-drug resistant gram negative bacteria.
Sepsis pathophysiology with particular interest in the role of the innate immune system; sepsis pathophysiology, management, and outcomes of HIV infected patients in sub-Saharan Africa.
Christopher C. Moore
Sepsis pathophysiology with particular interest in the role of the innate immune system; sepsis pathophysiology, management, and outcomes of HIV infected patients in sub-Saharan Africa.
Enteric diseases, molecular diagnostics and infectious disease epidemiology.
James A Platts-Mills
Enteric diseases, molecular diagnostics and infectious disease epidemiology.
Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity
Costi D. Sifri
Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity
Molecular diagnostics; Polio eradication; tracking immunity and virus shedding after oral polio vaccination in resource-challenged countries.
Mami Taniuchi
Molecular diagnostics; Polio eradication; tracking immunity and virus shedding after oral polio vaccination in resource-challenged countries.
Prevention and treatment of C. difficile infection. Role of microbiota in health and disease. Infections in special populations- elderly, pregnant women and racial/ethnic minority groups.
Cirle Alcantara Warren
Prevention and treatment of C. difficile infection. Role of microbiota in health and disease. Infections in special populations- elderly, pregnant women and racial/ethnic minority groups.
Parasitology/International Health
International health research has long been a focus and strength of the division. Faculty not only work on pathogens of global concern, they do so in collaboration with overseas investigators and at partner study sites in Brazil, Bangladesh, Tanzania, Uganda and elsewhere. Many of these sites represent long-standing partnerships cultivated over years of grant-supported study.
Areas of investigation include diarrheal pathogens, malaria, diagnostics for Mycobacterium tuberculosis, the impact of childhood malnutrition, and the genetics of disease susceptibility.
The following interdisciplinary faculty conduct research and instruct fellows in this area:
Amebiasis vaccine development; biomarkers of Clostridium difficile disease severity
Mayuresh Abhyankar
Amebiasis vaccine development; biomarkers of Clostridium difficile disease severity
Identification of Parasite Virulence Factors
Carol A. Gilchrist
Identification of Parasite Virulence Factors
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Jennifer Guler
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Multidrug resistant tuberculosis (MDR-TB); pharmacokinetics; clinical application of diagnostics for TB; clinical trials to optimize TB treatment; chronic illness/ TB integration
Scott K. Heysell
Multidrug resistant tuberculosis (MDR-TB); pharmacokinetics; clinical application of diagnostics for TB; clinical trials to optimize TB treatment; chronic illness/ TB integration
Molecular diagnostics, Tuberculosis, Global Health
Eric R. Houpt
Molecular diagnostics, Tuberculosis, Global Health
Sepsis pathophysiology with particular interest in the role of the innate immune system; sepsis pathophysiology, management, and outcomes of HIV infected patients in sub-Saharan Africa.
Christopher C. Moore
Sepsis pathophysiology with particular interest in the role of the innate immune system; sepsis pathophysiology, management, and outcomes of HIV infected patients in sub-Saharan Africa.
Enteric diseases, molecular diagnostics and infectious disease epidemiology.
James A Platts-Mills
Enteric diseases, molecular diagnostics and infectious disease epidemiology.
Molecular diagnostics; Polio eradication; tracking immunity and virus shedding after oral polio vaccination in resource-challenged countries.
Mami Taniuchi
Molecular diagnostics; Polio eradication; tracking immunity and virus shedding after oral polio vaccination in resource-challenged countries.
Pathogenesis & Host Responses to Infectious Agents
Microbial pathogens, host responses to infection, and pathogen manipulation of host cell biology are the focus of investigation for UVA faculty from a range of disciplines. Many are members of the Carter Immunology Center and the Myles H. Thaler Center for AIDS and Human Retrovirus Research.
The following interdisciplinary faculty conduct research and instruct fellows in this area:
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Herve Agaisse, PhD
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.<br> Cell Biology of bacterial pathogenesis. <br>The innate immune response to bacterial infection.
James E. Casanova
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.<br> Cell Biology of bacterial pathogenesis. <br>The innate immune response to bacterial infection.
Cellular and molecular mechanisms of Neisserial pathogenesis
Alison K. Criss
Cellular and molecular mechanisms of Neisserial pathogenesis
Host/pathogen Interaction - Chlamydia Infection
Isabelle Derre
Host/pathogen Interaction - Chlamydia Infection
Immune regulation for HCV infection and chronic liver inflammation
Young S. Hahn
Immune regulation for HCV infection and chronic liver inflammation
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Melissa M. Kendall
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity
Costi D. Sifri
Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity
Prevention and treatment of C. difficile infection. Role of microbiota in health and disease. Infections in special populations- elderly, pregnant women and racial/ethnic minority groups.
Cirle Alcantara Warren
Prevention and treatment of C. difficile infection. Role of microbiota in health and disease. Infections in special populations- elderly, pregnant women and racial/ethnic minority groups.
Virology & HIV
Virology research at UVA utilizes a number of approaches, including immunology, cell biology, structural biology and cancer biology, to study viruses that include influenza, hepatitis C, Ebola, dengue, KSHV and HIV.
Much of the basic research in HIV is conducted at the Myles H. Thaler Center for AIDS and Human Retrovirus Research, a community of infectious disease and immunology experts that ranks among the best in the nation. Researchers address fundamental questions about how HIV replicates at the cellular and molecular level, and how AIDS develops.
Immune regulation for HCV infection and chronic liver inflammation
Young S. Hahn
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Marie-Louise Hammarskjold
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
David M. Rekosh
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation