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Gregory R. Madden

Gregory R. Madden

Assistant Professor of Medicine, Medicine- Infectious Diseases and International Health

Primary Location
PO Box 801340
Charlottesville, VA 22908
Primary Phone Number
Fax Number
888.869.7448

Bio & Overview

Gregory Madden, is an Infectious Diseases Fellow at UVA. He is a returning UVA Med Alum and completed his Residency at Yale University. Dr. Madden is a physician scientist interested in enhancing the diagnosis and prevention of healthcare-associated infections. Working with the UVA Office of Hospital Epidemiology, he developed and analyzed a successful computerized algorithm to improve C. difficile test utilization. His current projects include: improving infection control practices at a hospital in Rwanda, quantifying the cost of C. difficile overdiagnosis, and developing an integrative model using immune biomarkers to predict outcomes of C. difficile infection.

Academic Information

Department
Medicine- Infectious Diseases and International Health

Primary Education

  • BA, Biology (minor: Biochemistry), University of Delaware, 2008
  • MD, Medicine, University of Virginia, 2012

Research Interests

Using immune biomarkers to predict outcomes of C. difficile infection

Selected Publications

2024

Madden, G. R., Boone, R. H., Lee, E., Sifri, C. D., & Petri Jr, W. A. (2024). Predicting Clostridioides dif fi cile infection outcomes with explainable machine learning. EBIOMEDICINE, 106. doi:10.1016/j.ebiom.2024.105244

Kamruzzaman, M., Heavey, J., Song, A., Bielskas, M., Bhattacharya, P., Madden, G., . . . Vullikanti, A. (2024). Improving Risk Prediction of Methicillin-Resistant Staphylococcus aureus Using Machine Learning Methods With Network Features: Retrospective Development Study.. JMIR AI, 3, e48067. doi:10.2196/48067

Boone, R. H., Lee, E., Petri, W. A., & Madden, G. R. (2024). Validation of clinical risk tools for recurrent Clostridioides difficile infection. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY. doi:10.1017/ice.2024.75

Rigo, I., Young, M. K., Abhyankar, M. M., Xu, F., Ramakrishnan, G., Naz, F., . . . Petri, W. A. (2024). The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection. ANAEROBE, 87. doi:10.1016/j.anaerobe.2024.102842

Ramakrishnan, G., Young, M. K., Nayak, U., Rigo, I., Marrs, A. S., Gilchrist, C. A., . . . Petri, W. A. (2024). Systemic neutrophil degranulation and emergency granulopoiesis in patients with Clostridioides difficile infection. ANAEROBE, 87. doi:10.1016/j.anaerobe.2024.102840

Hicks, A. S., Dolan, M. A., Shah, M. D., Elwood, S. E., Platts-Mills, J. A., Madden, G. R., . . . Eby, J. C. (2024). Early Initiation of Ceftaroline-Based Combination Therapy for Methicillin-resistant Staphylococcus aureus Bacteremia.. Res Sq. doi:10.21203/rs.3.rs-4095478/v1

Cui, J., Heavey, J., Lin, L., Klein, E. Y., Madden, G. R., Sifri, C. D., . . . Prakash, B. A. (2024). Modeling relaxed policies for discontinuation of methicillin-resistant Staphylococcus aureus contact precautions. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY. doi:10.1017/ice.2024.23

2023

Madden, G. R., Rigo, I., Boone, R., Abhyankar, M. M., Young, M. K., Basener, W., & Petri Jr, W. A. A. (2023). Novel Biomarkers, Including tcdB PCR Cycle Threshold, for Predicting Recurrent Clostridioides difficile Infection. INFECTION AND IMMUNITY, 91(4). doi:10.1128/iai.00092-23

O'Connor, L. F., Madden, G. R., Stone, D., Classen, D. C., & Eby, J. C. (2023). Risk Factors for Severe COVID-19 Among Health Care Workers. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 65(6), 529-532. doi:10.1097/JOM.0000000000002843

2022

Madden, G. R., Petri, W. A. J., Costa, D. V. S., Warren, C. A., Ma, J. Z., & Sifri, C. D. (2022). Validation of Clinical Risk Models for Clostridioides difficile-Attributable Outcomes. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 66(7). doi:10.1128/aac.00676-22

Phillips, E. C., Warren, C. A., Ma, J. Z., & Madden, G. R. (2022). Impact of Tigecycline on C. difficile Outcomes: Case Series and Propensity-Matched Retrospective Study. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 66(6). doi:10.1128/aac.00001-22

Sturek, J. M., Thomas, T. A., Gorham, J. D., Sheppard, C. A., Raymond, A. H., Petros De Guex, K., . . . Heysell, S. K. (2022). Convalescent Plasma for Preventing Critical Illness in COVID-19: a Phase 2 Trial and Immune Profile.. Microbiology spectrum, 10(1), e0256021. doi:10.1128/spectrum.02560-21

Young, M. K., Leslie, J. L., Madden, G. R., Lyerly, D. M., Carman, R. J., Lyerly, M. W., . . . Petri, W. A. J. (2022). Binary Toxin Expression by Clostridioides difficile Is Associated With Worse Disease. OPEN FORUM INFECTIOUS DISEASES, 9(3). doi:10.1093/ofid/ofac001

2021

Phillips, E. C., Warren, C. A., & Madden, G. (2021). 697. Outcomes of Tigecycline Use for Clostridioides difficile Infection: A Case Series of 28 Patients. Open forum infectious diseases, 8(Suppl 1), 449.

Dolan, M., Shah, M., Platts-Mills, J. A., Elliott, Z., Madden, G., & Eby, J. (2021). 190. Outcomes of Early Ceftaroline-based Combination Therapy for Methicillin-resistant Staphylococcus aureus Bacteremia. Open forum infectious diseases, 8(Suppl 1), S203.

Madden, G., Bielskas, M., Kamruzzaman, M., Bhattacharya, P., Lewis, B., Klein, E., . . . Vullikanti, A. (2021). 173. Deciphering COVID-19-Associated Effects on Hospital MRSA Transmission and Social Networks. Open forum infectious diseases, 8(Suppl 1), S104-S106.

Sturek, J. M., Thomas, T. A., Gorham, J. D., Sheppard, C. A., Raymond, A. E., De Guex, K. P., . . . Heysell, S. K. (2022). Convalescent Plasma for Preventing Critical Illness in COVID-19: a Phase 2 Trial and Immune Profile. MICROBIOLOGY SPECTRUM, 10(1). Retrieved from https://www.webofscience.com/

Mvukiyehe, J. P., Tuyishime, E., Ndindwanimana, A., Rickard, J., Manzi, O., Madden, G. R., . . . Banguti, P. R. (2021). Improving hand hygiene measures in low-resourced intensive care units: experience at the Kigali University Teaching Hospital in Rwanda.. International journal of infection control, 17, 20585. doi:10.3396/ijic.v17.20585

2020

Madden, G. R., Smith, D. C., Poulter, M. D., & Sifri, C. D. (2021). Propensity-Matched Cost of Clostridioides difficile Infection Overdiagnosis. OPEN FORUM INFECTIOUS DISEASES, 8(2). doi:10.1093/ofid/ofaa630

Abhyankar, M. M., Ma, J. Z., Scully, K. W., Nafziger, A. J., Frisbee, A. L., Saleh, M. M., . . . Petri, W. A. J. J. (2020). Immune Profiling To Predict Outcome of Clostridioides difficile Infection. MBIO, 11(3). doi:10.1128/mBio.00905-20

Madden, G. R., Enfield, K. B., & Sifri, C. D. (2020). Patient Outcomes With Prevented vs Negative Clostridioides difficile Tests Using a Computerized Clinical Decision Support Tool. OPEN FORUM INFECTIOUS DISEASES, 7(4). doi:10.1093/ofid/ofaa094

2019

Madden, G. R., Shirley, D. -A., Townsend, G., & Moonah, S. (2019). Case Report: Lower Gastrointestinal Bleeding due to Entamoeba histolytica Detected Early by Multiplex PCR: Case Report and Review of the Laboratory Diagnosis of Amebiasis. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 101(6), 1380-1383. doi:10.4269/ajtmh.19-0237

Madden, G. R., Fleece, M. E., Gupta, A., Lopes, M. B. S., Heysell, S. K., Arnold, C. J., & Wispelwey, B. (2019). HIV-Associated Vacuolar Encephalomyelopathy. OPEN FORUM INFECTIOUS DISEASES, 6(10). doi:10.1093/ofid/ofz366

Madden, G. R., Poulter, M. D., Crawford, M. P., Wilson, D. S., & Donowitz, G. R. (2019). Case report: Anaerobiospirillum prosthetic joint infection in a heart transplant recipient. BMC MUSCULOSKELETAL DISORDERS, 20. doi:10.1186/s12891-019-2684-z

Madden, G. R., & Sifri, C. D. (2019). Reduced Clostridioides difficile Tests Among Solid Organ Transplant Recipients Through a Diagnostic Stewardship Bundled Intervention. ANNALS OF TRANSPLANTATION, 24, 304-311. doi:10.12659/AOT.915168

2018

Madden, G. R., Cox, H. L., Poulter, M. D., Lyman, J. A., Enfield, K. B., & Sifri, C. D. (2019). Cost Analysis of Computerized Clinical Decision Support and Trainee Financial Incentive for Clostridioides difficile Testing. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 40(2), 242-244. doi:10.1017/ice.2018.300

Madden, G. R., Poulter, M. D., & Sifri, C. D. (2019). PCR cycle threshold to assess a diagnostic stewardship intervention for C. difficile testing. JOURNAL OF INFECTION, 78(2), 161-162. doi:10.1016/j.jinf.2018.09.013

Madden, G. R., Heon, B. E., & Sifri, C. D. (2018). Effect of copper-impregnated linens on multidrug-resistant organism acquisition and Clostridium difficile infection at a long-term acute-care hospital. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 39(11), 1384-1386. doi:10.1017/ice.2018.196

Madden, G. R., Poulter, M. D., & Sifri, C. D. (2018). Diagnostic stewardship and the 2017 update of the IDSA-SHEA Clinical Practice Guidelines for Clostridium difficile Infection. DIAGNOSIS, 5(3), 119-125. doi:10.1515/dx-2018-0012

Madden, G. R., & Sifri, C. D. (2018). Antimicrobial Resistance to Agents Used for Staphylococcus aureus Decolonization: Is There a Reason for Concern?. CURRENT INFECTIOUS DISEASE REPORTS, 20(8). doi:10.1007/s11908-018-0630-0

Madden, G. R., Mesner, I. G., Cox, H. L., Mathers, A. J., Lyman, J. A., Sifri, C. D., & Enfield, K. B. (2018). Reduced Clostridium difficile Tests and Laboratory-Identified Events With a Computerized Clinical Decision Support Tool and Financial Incentive. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 39(6), 737-740. doi:10.1017/ice.2018.53

Madden, G. R., Weinstein, R. A., & Sifri, C. D. (2018). Diagnostic Stewardship for Healthcare-Associated Infections: Opportunities and Challenges to Safely Reduce Test Use. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 39(2), 214-218. doi:10.1017/ice.2017.278

2015

Madden, G. R., Argraves, S. M., Van Ness, P. H., & Juthani-Mehta, M. (2015). Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 36(3), 356-357. doi:10.1017/ice.2014.66

2012

Madden, G. R., Schmitz, K. H., & Fullerton, K. (2012). A Case of Infantile Star Anise Toxicity. PEDIATRIC EMERGENCY CARE, 28(3), 284-285. doi:10.1097/PEC.0b013e3182495ba7

2010

Costa, L. B., Madden, G., Sevilleja, J. E., Warren, C. A., Roche, J. K., & Guerrant, R. L. (2010). CPG-ODN, ARGININE OR ALANYL-GLUTMINE REDUCE CRYPTOSPORIDIAL INFECTION IN MALNOURISHED HUMAN INTESTINAL EPITHELIAL CELLS. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 83(5), 98. Retrieved from https://www.webofscience.com/