Neuroscience

Neurobiology of the cardiovascular and respiratory system, Central mechanisms linking cardiorespiratory function with affective state and emotion

Psychiatry And Neurobehavioral Sciences

Systems biology approaches to study gene dosage in neurodevelopment and neurodevelopmental disorders

Mechanisms of neuromodulation in central neurons

Circuit mechanisms of sleep and epilepsy

Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders

Neuroscience

Neonatal brain injury, hypoxic-ischemic encephalopathy, neonatal seizures

The Neurobiology of Energy Balance

Mouse Visual System, physiology, functional imaging, genetics, molecular, behavioral, and computational methods

Herpes Simplex Virus Infection of Neurons

Regulation and Function Serotonergic Neurons During Development

Adult-born neurons, perineuronal nets, and microglia in hippocampal plasticity and behavior in health and disease

Neuron-glia and glial-glial interactions

Elucidating and Understanding the Mechanisms Underlying Nervous System Development

Uncovering the molecular etiology of neurodegenerative diseases

Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance

Developmental Plasticity and Neuropathology of Synaptic Circuitries.

Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics

Neuroscience

Brain metabolism, cognitive decline, cholesterol and Alzheimer's disease

Explicating psychological and neurobiological mechanisms of chronic pain.

Impact of APOE and lipid metabolism on cell function in Alzheimer's disease.

Exploring new therapeutics avenues to treat Multiple Sclerosis.

Circadian entrainment for the treatment of metabolic and neurodegenerative diseases

Immune response to infectious disease in the CNS

The Pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and other dementia-related disorders.

Neuronal circuits underlying infant behaviors, including sleep and social behavior

Seizures, neuronal excitability and plasticity

Neuroscience

The role of glia in the development, maintenance and regeneration of the nervous system

Neural tissue engineering, biomaterials, drug delivery, redox regulation of stem cell fate, engineering cell-interactive microenvironments

Plastic Surgery

Developing novel neuroprotection strategies to preserve vision in glaucoma

Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure

Neuron-glia communications, brain plasticity and homeostasis, glial responses to neurodegeneration

Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders

Anesthesiology

Behavioral Pharmacology, Sex Differences, Animal Models of Addiction

Neural Mechanisms of Pattern Learning and Recognition in the Auditory System

Neuroscience

Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders

Understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13) and temporal lobe epilepsy. My lab uses a number of experimental techniques including patch clamp electrophysiology and in vivo seizure monitor

Neurology

Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.

Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis

The Proctor Laboratory integrates systems biology with molecular, cellular, and systems neuroscience into a cutting-edge framework for investigation of multi-scale mechanisms of Alzheimer's disease risk, onset, and progression.

The Role of Melanopsin Retinal Ganglion Cells in the Photic Regulation of Mammalian Circadian Rhythms

Innate Inflammatory Pathways Associated with Acute Aneurysmal Subarachnoid Hemorrhage

Developmental Cognitive Neuroscience

Novel therapeutic approaches to brain cancers and to other neurologic diseases

Assembly and Plasticity of Neural Circuits

Psychiatry and Neurobehavioral Sciences

Anti-tumor immunity in brain tumors, Cancer Neuroscience

Auditory Neurobiology

Regulation of neural stem cell proliferation during development and adulthood

Sensory processing and plasticity

Role of Glia in Neurological Illnesses and Cancer

Gram-positive pathogenesis; type VII secretion; impact of secreted effectors on host-pathogen interactions and immune responses

Traumatic Brain Injury

Neuroscience

Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

Psychiatry And Neurobehavioral Sciences

Neural control of cardiorespiratory function in health and disease

Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.

Cardiovascular Development and Cerebrovascular Pathologies

Mechanisms of Huntington's Disease Pathogenesis

Single Cell Analysis

Neuroscience and Anesthetic Neuroprotection