Pharmacology

The Ubiquitin System and Human Cancer

Neurobiology of the cardiovascular and respiratory system, Central mechanisms linking cardiorespiratory function with affective state and emotion

Mechanisms of neuromodulation in central neurons

Circuit mechanisms of sleep and epilepsy

Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism

Immuno-Oncology, T cell therapy, TCR Discovery, Next generation cell therapy

Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging

Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics

Neuroscience

Brain metabolism, cognitive decline, cholesterol and Alzheimer's disease

Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression

Exploring new therapeutics avenues to treat Multiple Sclerosis.

Molecular mechanisms controlling insulin signaling and fat synthesis.

Immune response to infectious disease in the CNS

Translating our discoveries in the microcirculation to tangible benefits in patients.

Lung injury and repair, sepsis

Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

Composition, Biophysics and Physiology of Cellular Membranes

Chemical biology of sphingosine 1-phosphate

Behavioral Pharmacology, Sex Differences, Animal Models of Addiction

Pharmacology

Identifying tumor selective drug targets, Understanding the genetic drivers of tumor immune evasion

Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.

Chromosome segregation and aneuploidy in meiosis and mitosis

Roles of complex signaling networks involved in the regulation of cardiovascular function and disease

Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

Proteoform Systems Biology: proteogenomic approaches to uncover the role of proteomic variation in human disease

Identify the calcium signaling abnormalities that lead to vascular dysfunction and blood pressure elevation in cardiovascular disorders

Role of endoplasmic reticulum-associated protein degradation in health and disease

Iron metabolism and Immunometabolism in inflammation and autoimmune diseases

Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.

Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.