Pornillos, Owen
Primary Appointment
Professor, Molecular Physiology and Biological Physics
Education
- BS, Molecular Biology and Biotechnology, University of the Philippines
- PhD, Biochemistry, University of Utah
Contact Information
480 Ray C Hunt Dr
Snyder Bldg, Rm 221
Charlottesville, VA 22908
Telephone: 434-982-6063
Email: owp3a@virginia.edu
Website: http://pornillos-lab.faculty.virginia.edu
Research Disciplines
Biochemistry, Biophysics, Biotechnology, Immunology, Infectious Diseases/Biodefense, Microbiology, Molecular Biology, Physiology, Structural Biology
Research Interests
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Research Description
Our long-term goals are to understand how proteins interact with each other and how these interactions underlie biological processes. We are particularly interested in molecular and structural switches that control how proteins form high-order quaternary interactions, or macromolecular assemblies. We use X-ray crystallography and cryoEM to determine the structures of individual proteins, protein-protein complexes, and assemblies. To test mechanistic models that arise from these structures, we use biochemical approaches to reconstitute viral and cellular assembly pathways in vitro.
List of Publications in Pubmed