UVA Author: Chan Choo Yap
Citation: Yap CC, Winckler B. Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis. Dev Cell. 2021;56(10):1361-1362. doi:10.1016/j.devcel.2021.04.024
DOI: https://www.sciencedirect.com/science/article/pii/S1534580721003622?via%3Dihub
Pub-Med Number: 34004149
Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. Roney et al. report that immature autophagosomes accumulate in axons because cholesterol-laden lysosomes in the soma are not transported to the axon for autophagosome fusion and maturation because they aberrantly sequester non-functioning kinesin-1.