UVA Author: Noelle Dwyer
Citation: Little JN, Dwyer ND. Cep55: abscission boss or assistant?. Trends Cell Biol. 2021;31(10):789-791. doi:10.1016/j.tcb.2021.07.006
DOI: https://doi.org/10.1016/j.tcb.2021.07.006
Pub-Med Number: 34400044
Abscission is the second stage of cytokinesis. Cep55, a coiled-coil protein, is thought to recruit endosomal sorting complexes required for transport (ESCRTs) to the midbody to complete abscission. However, recent studies of Cep55-knockout mice reveal that most cells can complete abscission without Cep55. More work is needed to understand abscission mechanisms in different cell types.