Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling

9/4/2024

UVA Author: Xiaowei Lu Citation: Xie N, Landin Malt A, Adylkhan A, Rodeman N, Moraes Borges R, Hwang D, Liu A, Smith C, Hogan A, Lu X. Wnt7b acts in…

Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates

5/30/2024

UVA Author: Arabinda Mandal Citation: Mandal A, Shetty J, Tran CA, Olson WC, Mandal M, Ban B, Pires ES, Adair SJ, Bauer TW, Slingluff CL Jr, Herr JC. Cancer-oocyte SAS1B…

The Chlamydomonas flagellar membrane and its dynamic properties

5/2/2024

UVA Author: Robert Bloodgood Citation: DOI: Pub-Med Number: This chapter overviews a membrane bound organelle and describes its dynamic properties. The plasma membrane of a Chlamydomonas cell must have at least…

Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

3/25/2024

UVA Author: Gael Genet Citation: Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson…

Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction

3/25/2024

UVA Author: Nicholas Chavkin Citation: Cochran JD, Yura Y, Thel MC, Doviak H, Polizio AH, Arai Y, Arai Y, Horitani K, Park E, Chavkin NW, Kour A, Sano S, Mahajan…

Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans

3/25/2024

UVA Author: Nicholas Chavkin Citation: Chavkin NW, Vippa T, Jung C, McDonnell S, Hirschi KK, Gokce N, Walsh K. Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans.…

Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium

3/25/2024

UVA Author: Nicholas Chavkin Citation: Dunaway LS, Luse MA, Nyshadham S, Bulut G, Alencar GF, Chavkin NW, Cortese-Krott M, Hirschi KK, Isakson BE. Obesogenic diet disrupts tissue-specific mitochondrial gene signatures…

Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages

3/25/2024

UVA Author: Yinyu Wu Citation: Wilcox NS, Yarovinsky TO, Pandya P, Ramgolam VS, Moro A, Wu Y, Nicoli S, Hirschi KK, Bender JR. Distinct hypoxia-induced translational profiles of embryonic and…

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

3/25/2024

UVA Author: Josh Wythe Citation: Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen…

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

3/25/2024

UVA Author: Laura Newman Citation: Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S,…