Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels

11/8/2024

General, open-source vertex modeling in biological applications using Tissue Forge

9/23/2024

UVA Author: Tien Comlekoglu Citation: Sego TJ, Comlekoglu T, Peirce SM, Desimone DW, Glazier JA. General, open-source vertex modeling in biological applications using Tissue Forge. Sci Rep. 2023 Oct 19;13(1):17886.…

Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of Xenopus mesendoderm

9/23/2024

UVA Author: Tien Comlekoglu Citation: Comlekoglu T, Dzamba BJ, Pacheco GG, Shook DR, Sego TJ, Glazier JA, Peirce SM, DeSimone DW. Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry…

Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling

9/4/2024

UVA Author: Xiaowei Lu Citation: Xie N, Landin Malt A, Adylkhan A, Rodeman N, Moraes Borges R, Hwang D, Liu A, Smith C, Hogan A, Lu X. Wnt7b acts in…

Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system

8/19/2024

Authors: Shaylyn Clancy, Nicholas Xie, Tess Eluvathingal Muttikkal, Jasmine Wang, Aray Adylkhan, Esha Fateh, Margaret Smith, Phillip Wilson, Matthew Smith, Arielle Hogan, Ann Sutherland, Xiaowei Lu Citation: Clancy S, Xie…

Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates

5/30/2024

UVA Author: Arabinda Mandal Citation: Mandal A, Shetty J, Tran CA, Olson WC, Mandal M, Ban B, Pires ES, Adair SJ, Bauer TW, Slingluff CL Jr, Herr JC. Cancer-oocyte SAS1B…

The Chlamydomonas flagellar membrane and its dynamic properties

5/2/2024

UVA Author: Robert Bloodgood Citation: DOI: Pub-Med Number: This chapter overviews a membrane bound organelle and describes its dynamic properties. The plasma membrane of a Chlamydomonas cell must have at least…

Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

3/25/2024

UVA Author: Gael Genet Citation: Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson…

Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction

3/25/2024

UVA Author: Nicholas Chavkin Citation: Cochran JD, Yura Y, Thel MC, Doviak H, Polizio AH, Arai Y, Arai Y, Horitani K, Park E, Chavkin NW, Kour A, Sano S, Mahajan…

Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans

3/25/2024

UVA Author: Nicholas Chavkin Citation: Chavkin NW, Vippa T, Jung C, McDonnell S, Hirschi KK, Gokce N, Walsh K. Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans.…