Category: Featured Publications

Single Cell Analysis in Vascular Biology

The ability to quantify DNA, RNA, and protein variations at the single cell level has revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses, individual cells within populations…

Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone

Stem cell therapies demonstrate promising results as treatment for neurological disease and injury, owing to their innate ability to enhance endogenous neural tissue repair and promote functional recovery. However, delivery…

Endothelial cell development and its application to regenerative medicine

The formation and remodeling of a functional circulatory system is critical for sustaining prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells require further specification to create the unique…

Molecular regulation of arteriovenous endothelial cell specification

The systemic circulation depends upon a highly organized, hierarchal blood vascular network that requires the successful specification of arterial and venous endothelial cells during development. This process is driven by…

Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development

Building a brain of the proper size and structure requires neural stem cells (NSCs) to divide with tight temporal and spatial control to produce different daughter cell types in proper…

Imaging and quantitative analysis of cytokinesis in developing brains of Kinesin-6 mutant mice.

Cytokinesis in neural progenitors occurs with specialized constraints due to their highly polarized structure and the need for both symmetric and asymmetric divisions. They must produce proper numbers of progenitors,…

The Chlamydomonas flagellar membrane glycoprotein FMG-1B is necessary for expression of force at the flagellar surface.

  Robert A. Bloodgood, Joseph Tetreault, and Roger D. Sloboda Journal of Cell Science (2019) 132, jcs233429. doi:10.1242/jcs.233429

Nestin in immature embryonic neurons affects axon growth cone morphology and Semaphorin3a sensitivity.

Correct wiring in the neocortex requires that responses to an individual guidance cue vary among neurons in the same location, and within the same neuron over time. Nestin is an…

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway.

Proper chromosome segregation depends upon kinetochore phosphorylation by the Chromosome Passenger Complex (CPC). Current models suggest the activity of the CPC decreases in response to the inter-kinetochore stretch that accompanies…