Estrogens and development of the rete testis, efferent ductules, epididymis and vas deferens
7/2/2021
Estrogen has always been considered the female hormone and testosterone the male hormone. However, estrogen's presence in the testis and deleterious effects of estrogen treatment during development have been known…
Vascular endothelial cell specification in health and disease
7/2/2021
There are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries oxygen, nutrients, circulating cells, and soluble…
7/2/2021
During development, sensory hair cells (HCs) in the cochlea assemble a stereociliary hair bundle on their apical surface with planar polarized structure and orientation. We have recently identified a non-canonical,…
Regulation of Hemogenic Endothelial Cell Development and Function
7/2/2021
Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells (HSPCs) essential for establishment and maintenance of the adult blood system. This process requires the specification of a subset of vascular…
Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
7/2/2021
Blood vessels are ubiquitously distributed within all tissues of the body and perform diverse functions. Thus, derivation of mature vascular endothelial cells, which line blood vessel lumens, from human pluripotent…
The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation
7/2/2021
Background A hallmark of heart failure is cardiac fibrosis, which results from the injury-induced differentiation response of resident fibroblasts to myofibroblasts that deposit extracellular matrix. During myofibroblast differentiation, fibroblasts progress…
The Renin Cell Baroreceptor, A Nuclear Mechanotransducer Central for Homeostasis
5/17/2021
Rationale: Renin-expressing cells are myoendocrine cells crucial for survival. They have been postulated to possess a pressure-sensing mechanism, a baroreceptor, which can detect slight changes in blood pressure and respond…
5/6/2021
Upon infection of host cells, Salmonella enterica serovar Typhimurium resides in a modified-endosomal compartment referred to as the Salmonella-containing vacuole (SCV). SCV biogenesis is driven by multiple effector proteins translocated…
Tissue-Resident Macrophage Development and Function
1/28/2021
Tissue-resident macrophages have been associated with important and diverse biological processes such as native immunity, tissue homeostasis and angiogenesis during development and postnatally. Thus, it is critical to understand the…