Ryan Mulligan

My project seeks to understand the response of endosomes, specifically those containing mannose-6-phosphote receptor (M6PR), or the late endosomal protein Rab7a, to lysosomal membrane damage states within the nervous system. I am interested in understanding the cumulative behavior of both M6PR and Rab7 vesicular compartments, and how this behavior is coordinated with lysosome specific autophagy and lysosomal membrane repair processes. Further, as Rab7a is mutated in the peripheral neuropathy Charcot Marie Tooth 2B, I am interested in investigating Rab7a driven lysosomal damage responses in a model of this disease.