Shaylyn Clancy

July 7, 2021 by

My research focuses on the mechanisms behind axon guidance in the developing mammalian cochlea.  During development, type II spiral ganglion neuron axons extend into the sensory epithelium of the cochlea and make a 90 degree turn towards the cochlear base, but the mechanisms behind this remarkable innervation pattern are largely unknown. I am investigating the role planar cell polarity signaling plays in directing the turning pattern of these axons. Specifically, I am examining the effects of planar cell polarity signaling on both extracellular matrix composition and the mechanical environment of the cochlea, and determining if type II spiral ganglion neurons are sensitive to these effects.