T1DGC Study Results Published in Diabetes

“Tests for Genetic Interactions in Type 1 Diabetes – Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs” authored by Type 1 Diabetes Genetics Consortium members (including CPHG Director Steve Rich, PhD, Associate Director Pat Concannon, PhD, and Assistant Professor Wei-Min Chen, PhD) was published in the March 2011 issue of Diabetes. The objective of this study was to look beyond the many common genetic variants associated with type 1 diabetes risk and to more fully explain familial clustering of this disease. The Consortium recruited 3,892 families for this study and after genotyping 6,090 markers, linkage analyses of these families were performed. The is the largest linkage study reported for any disease and their findings indicate there are no major type 1 diabetes subtypes definable by linkage analyses.