Mete Civelek

Civelek, Mete

Primary Appointment

Associate Professor, Biomedical Engineering


  • BA, Molecular Biology and Genetics, Bogazici University
  • BS, Chemical Engineering, Bogazici University
  • MS, Chemical Engineering, Pennsylvania State University, University Park, PA
  • PhD, Bioengineering, University of Pennsylvania

Contact Information

OMS, Room 3836A
PO Box 800717
Charlottesville, VA 22908
Telephone: 434-243-1669
Fax: 434-924-1312

Research Disciplines

Bioinformatics and Genomics, Biomedical Engineering, Cardiovascular Biology, Epigenetics, Experimental Pathology, Genetics, Metabolism, Molecular Pharmacology

Research Interests

Systems Genetics Approaches to Understand Cardiometabolic Traits

Research Description

The goal of our laboratory is to understand the genetic mechanisms that lead to increased susceptibility to cardiovascular and metabolic diseases. The interactions among hundreds of genes and gene networks along with environmental factors such as diet affect our health status. We use systems genetics to uncover this complexity. We use a range of experimental and computational methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or metabolite levels, in human and mouse populations. We also test our predictions using standard biochemistry and molecular biology approaches in cell cultures and animal models. Our results provided insights into both the molecular underpinnings of complex traits and the understanding of common, complex diseases.

Selected Publications