Publications

Salvati, K. A., Ritger, M. L., Davoudian, P. A., O’Dell, F., Wyskiel, D. R., Souza, G. M. P. R., . . . Beenhakker, M. P. (2022). AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures. BRAIN, 145(7), 2332-2346. doi:10.1093/brain/awac037

Upchurch, C. M., Yeudall, S., Pavelec, C. M., Merk, D., Greulich, J., Manjegowda, M., . . . Leitinger, N. (2022). Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis. SCIENCE ADVANCES, 8(28). doi:10.1126/sciadv.abn0050

Upchurch, C. M., Yeudall, S., Pavelec, C. M., Manjegowda, M., Bochkis, I. M., Scott, M., . . . Leitinger, N. (2022). Virus-induced Hepatic Expression of an Oxidized Phospholipid-binding Antibody Fragment Prevents Initiation of Hepatic Steatosis and Progression to Fibrosis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 Suppl 1. doi:10.1096/fasebj.2022.36.s1.l8081

Alexander, S. P. H., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., . . . Zhu, M. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. BRITISH JOURNAL OF PHARMACOLOGY, 178, S157-S245. doi:10.1111/bph.15539

Straub, J., Vitko, I., Gaykema, R. P., & Perez-Reyes, E. (2021). Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (174). doi:10.3791/62929

Correia Rocha, I. R., Perez-Reyes, E., & Chacur, M. (2021). Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 20(2), 293-301. doi:10.1007/s43630-021-00018-w

Shi, Y., Stornetta, D. S., Reklow, R. J., Sahu, A., Wabara, Y., Nguyen, A., . . . Bayliss, D. A. (2021). A brainstem peptide system activated at birth protects postnatal breathing. NATURE, 589(7842), 426-+. doi:10.1038/s41586-020-2991-4

Straub, J., Gawda, A., Ravichandran, P., McGrew, B., Nylund, E., Kang, J., . . . Perez-Reyes, E. (2020). Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy. EPILEPSIA, 61(10), 2277-2288. doi:10.1111/epi.16651

Wulczyn, K., Perez-Reyes, E., Nussbaum, R. L., & Park, M. (2019). Primary aldosteronism associated with a germline variant in CACNA1H. BMJ CASE REPORTS, 12(5). doi:10.1136/bcr-2018-229031

Nigam, A., Hargus, N. J., Barker, B. S., Ottolini, M., Hounshell, J. A., III, B. E. H., . . . Patel, M. K. (2019). Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy. EPILEPSY RESEARCH, 154, 132-138. doi:10.1016/j.eplepsyres.2019.05.006

Du, T. -T., Dewey, J. B., Wagner, E. L., Cui, R., Heo, J., Park, J. -J., . . . Shin, J. -B. (2019). LMO7 deficiency reveals the significance of the cuticular plate for hearing function. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-09074-4

Cottrell, G. S., Soubrane, C. H., Hounshell, J. A., Lin, H., Owenson, V., Rigby, M., . . . Stephens, G. J. (2018). CACHD1 is an alpha 2 delta-Like Protein That Modulates Ca(V)3 Voltage-Gated Calcium Channel Activity. JOURNAL OF NEUROSCIENCE, 38(43), 9186-9201. doi:10.1523/JNEUROSCI.3572-15.2018

Joshi, S., Sun, H., Rajasekaran, K., Williamson, J., Perez-Reyes, E., & Kapur, J. (2018). A novel therapeutic approach for treatment of catamenial epilepsy. NEUROBIOLOGY OF DISEASE, 111, 127-137. doi:10.1016/j.nbd.2017.12.009

Chemin, J., Taiakina, V., Monteil, A., Piazza, M., Guan, W., Stephens, R. F., . . . Spafford, J. D. (2017). Calmodulin regulates Ca(v)3 T-type channels at their gating brake. JOURNAL OF BIOLOGICAL CHEMISTRY, 292(49), 20010-20031. doi:10.1074/jbc.M117.807925

Becker, F., Reid, C. A., Hallmann, K., Tae, H. -S., Phillips, A. M., Teodorescu, G., . . . Maljevic, S. (2017). Functional variants in <i>HCN4</i> and <i>CACNA1H</i> may contribute to genetic generalized epilepsy.. Epilepsia open, 2(3), 334-342. doi:10.1002/epi4.12068

Lee, N., Jeong, S., Kim, K. -C., Kim, J. -A., Park, J. -Y., Kang, H. -W., . . . Lee, J. -H. (2017). Ca2+ Regulation of Ca(v)3.3 T-type Ca2+ Channel Is Mediated by Calmodulin. MOLECULAR PHARMACOLOGY, 92(3), 347-357. doi:10.1124/mol.117.108530

Shi, Y., Abe, C., Holloway, B. B., Shu, S., Kumar, N. N., Weaver, J. L., . . . Bayliss, D. A. (2016). Nalcn Is a “Leak” Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. JOURNAL OF NEUROSCIENCE, 36(31), 8174-8187. doi:10.1523/JNEUROSCI.1096-16.2016

Park, J., Yu, Y. P., Zhou, C. -Y., Li, K. -W., Wang, D., Chang, E., . . . Luo, Z. D. (2016). Central Mechanisms Mediating Thrombospondin-4-induced Pain States. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(25), 13335-13348. doi:10.1074/jbc.M116.723478

Warthen, D. M., Lambeth, P. S., Ottolini, M., Shi, Y., Barker, B. S., Gaykema, R. P., . . . Scott, M. M. (2016). Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 10. doi:10.3389/fnbeh.2016.00063

Karmazinova, M., Jaskova, K., Griac, P., Perez-Reyes, E., & Lacinova, L. (2015). Contrasting the roles of the I-II loop gating brake in Ca(V)3.1 and Ca(V)3.3 calcium channels. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467(12), 2519-2527. doi:10.1007/s00424-015-1728-y

Wang, G., Bochorishvili, G., Chen, Y., Salvati, K. A., Zhang, P., Dubel, S. J., . . . Zhu, J. J. (2015). Ca(V)3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. GENES & DEVELOPMENT, 29(14), 1535-1551. doi:10.1101/gad.260869.115

Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Bayliss, D. A. (2015). Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. SCIENCE, 348(6240), 1255-1260. doi:10.1126/science.aaa0922

Perez-Reyes, E., & Lee, J. -H. (2014). Ins and outs of T-channel structure function. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 466(4), 627-633. doi:10.1007/s00424-013-1419-5

Eckle, V. -S., Shcheglovitov, A., Vitko, I., Dey, D., Yap, C. C., Winckler, B., & Perez-Reyes, E. (2014). Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. JOURNAL OF PHYSIOLOGY-LONDON, 592(4), 795-809. doi:10.1113/jphysiol.2013.264176

Dey, D., Eckle, V. -S., Vitko, I., Sullivan, K. A., Lasiecka, Z. M., Winckler, B., . . . Perez-Reyes, E. (2014). A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. EPILEPSIA, 55(2), 203-213. doi:10.1111/epi.12472

Seo, H., Li, H. Y., Perez-Reyes, E., & Lee, J. -H. (2013). Effects of Eugenol on T-type Ca2+ Channel Isoforms. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 347(2), 310-317. doi:10.1124/jpet.113.207936

Shcheglovitov, A., Vitko, I., Lazarenko, R. M., Orestes, P., Todorovic, S. M., & Perez-Reyes, E. (2012). Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. JOURNAL OF GENERAL PHYSIOLOGY, 139(3), 219-234. doi:10.1085/jgp.201110699

Hargus, N. J., Jennings, C., Perez-Reyes, E., Bertram, E. H., & Patel, M. K. (2012). Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A1-receptor activation. EPILEPSIA, 53(1), 168-176. doi:10.1111/j.1528-1167.2011.03337.x

Karmazinova, M., Baumgart, J. P., Perez-Reyes, E., & Lacinova, L. (2011). The voltage dependence of gating currents of the neuronal CA(V)3.3 channel is determined by the gating brake in the I-II loop. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 461(4), 461-468. doi:10.1007/s00424-011-0937-2

Zamponi, G. W., Lory, P., & Perez-Reyes, E. (2010). Role of voltage-gated calcium channels in epilepsy. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 460(2), 395-403. doi:10.1007/s00424-009-0772-x

Strege, P. R., Sha, L., Beyder, A., Bernard, C. E., Perez-Reyes, E., Evangelista, S., . . . Farrugia, G. (2010). T-type Ca2+ channel modulation by otilonium bromide. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 298(5), G706-G713. doi:10.1152/ajpgi.00437.2009

Perez-Reyes, E. (2010). G Protein-Mediated Inhibition of Ca(v)3.2 T-Type Channels Revisited. MOLECULAR PHARMACOLOGY, 77(2), 136-138. doi:10.1124/mol.109.062133

Kang, H. -W., Vitko, I., Lee, S. -S., Perez-Reyes, E., & Lee, J. -H. (2010). Structural Determinants of the High Affinity Extracellular Zinc Binding Site on Ca(v)3.2 T-type Calcium Channels. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(5), 3271-3281. doi:10.1074/jbc.M109.067660

Perez-Reyes, E. (2010). Characterization of the gating brake in the I-II loop of Ca(V)3 T-type calcium channels. CHANNELS, 4(6), 453-458. doi:10.4161/chan.4.6.12889