Resource Statement

Spatial Biology Core (SBC) brings the most modern research for studying cellular and molecular interactions in the spatial context of tissues and organs. The spatial analysis combines single-cell, spatial RNA sequencing, high-resolution microscopy, and quantitative image data analysis to enable large-scale spatial genomics and proteomics studies. The SBC Core supports the iPSC and organoids culture offering scientific consultation, cell maintenance, and renting lab space for groups that need a space for that. We also prepare samples for RNA and single-cell analysis.  

Our analyzes included:  

1. i) Multiplex Analysis

–  NanoString nCounter, RNA expression. 

–  Isoplexis, a single-cell proteomics. 

1. ii) Spatial Analysis

–  NanoString CosMx SMI, high-plex in situ multi-omics analysis.  

– NanoString GeoMx DSP, morphological context in spatial transcriptomics and spatial proteomics analysis. 

– ZellScanner ChipCytometry, combined with advanced imaging software, single-cell resolution microscopy imaging. 

iii) Confocal and Non-confocal image 

–  Perkin Elmer Operetta CLS high-content imaging system 

iv) Generate Single Cell Clone

–  Cell Raft – Cell Microsystems 

The Core Facility is on the first floor of Pinn Hall and has open-access investigators.