UVA CLEAR: Center for Leading Edge Addiction Research

The University of Virginia’s Center for Leading Edge Addiction Research or CLEAR clinic is the site of ongoing research studies on substance abuse for the Department of Psychiatry and Neurobehavioral Sciences’ Division of Neurobiological Studies.

Through our research, we hope to bring new knowledge to better understand the biological underpinning of addiction. Our approach combines medications, which target different brain pathways known to be involved in the rewarding effects of drugs, with behavior-changing techniques in an effort to reduce craving associated with substance abuse.

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UVA CLEAR is committed to researching new treatment methods that may help individuals on their way to recovery. Our center began enrolling research participants in March 2005.

Appointment information

Dr. Nassima Ait-Daoud Tiouririne

Center Director

Dr. Nassima Ait-Daoud Tiouririne's special interests are medication development for the treatment of addiction and understanding the underpinnings of drug cravings associated with treatment response.

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UVA CLEAR is seeking adults ages 18 and older to participate in a research study for individuals who use cocaine and are not currently seeking treatment to stop. The purpose of this study is to determine the safety and tolerability of low-intensity focused ultrasound on the individuals with a diagnosis of cocaine use disorder.


UVA CLEAR provides a helpline to residents of Virginia which offers support and education to individuals who are struggling with any substance use disorder. Referrals will be provided to treatment, counseling, or other resources in your area. Family or friends are also welcome to call for advice and guidance.