UVA CLEAR: Center for Leading Edge Addiction Research

The University of Virginia’s Center for Leading Edge Addiction Research or CLEAR clinic is the site of ongoing research studies on substance abuse for the Department of Psychiatry and Neurobehavioral Sciences’ Division of Neurobiological Studies.

Through our research, we hope to bring new knowledge to better understand the biological underpinning of addiction. Our approach combines medications, which target different brain pathways known to be involved in the rewarding effects of drugs, with behavior-changing techniques in an effort to reduce craving associated with substance abuse.

Panel of experts discuss opioid crisis

Opioid Crisis

Technology is key to addressing opioid epidemic, according to experts.

Read More

Photo of woman admiring sunrise


UVA CLEAR is committed to researching new treatment methods that may help individuals on their way to recovery. Our center began enrolling research participants in March 2005.

Appointment information

Dr. Nassima Ait-Daoud Tiouririne

Center Director

Dr. Nassima Ait-Daoud Tiouririne's special interests are medication development for the treatment of addiction and understanding the underpinnings of drug cravings associated with treatment response.

Learn More


We are seeking adults ages 18 to 55 who want to stop their cannabis usage to participate in a research study to test the effectiveness of an investigational medication. The purpose of the study is to see if the investigational drug is effective in reducing withdrawal symptoms in individuals who are motivated to eliminate their regular cannabis usage.


UVA CLEAR is seeking adults ages 18 and older to participate in a research study for individuals who use cocaine and are not currently seeking treatment to stop. The purpose of this study is to determine the safety and tolerability of low-intensity focused ultrasound on the individuals with a diagnosis of cocaine use disorder.


UVA CLEAR provides a helpline to residents of Virginia which provides support and education to individuals who are struggling with opioid use or who may have a prescription for opioids for the management of pain. Family or friends are also welcome to call for advice or information.