Agaisse, Herve

Primary Appointment

Professor, Microbiology, Immunology, and Cancer Biology

Education

PhD, Microbiology, Pasteur Institute
Postdoc, , Harvard Medical School

Contact Information

Pinn Hall, 7th floor, Room 7221
Charlottesville, VA 22908
Fax: 434.982.1071
Email: hfa5y@virginia.edu
Website: https://mic.med.virginia.edu/agaisse/

Research Disciplines

Biophysics & Structural Biology, Computational Biology, Genetics, Immunology, Infectious Diseases/Biodefense, Microbiology, Molecular Biology

Research Interests

Genetic approaches, cellular and molecular biology of intracellular pathogen infection

Research Description

The Agaisse Lab is associated with the Department of Microbiology, Immunology, and Cancer Biology (MIC). Our laboratory studies the bacterial pathogen Shigella flexneri, which causes approximately 270 million cases of bacillary dysentery (blood in stool) worldwide every year, resulting in more than 200,000 deaths. Our objective is to understand the molecular and cellular mechanisms supporting the disease in order to rationally design therapeutic interventions. We utilize a multi-disciplinary approach integrating molecular and cellular microbiology, bacterial and host cell genomics, bioinformatics and unique animal models of pathogenesis.