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Judith A. Woodfolk, MD, PhD

JUDITH WOOLFOLKPRIMARY APPOINTMENT:

Professor of Medicine

CONTACT:

UVA Division of Asthma, Allergy, and Clinical Immunology
PO Box 801355
MR-4, 5061
Telephone: 434-924-1293 / 434-982-3958
Fax: 434-924-1251
Email: jaw4m@virginia.edu

 

RESEARCH AREAS:

Immunology, Microbiology, Molecular Biology, Translational Science

RESEARCH SUMMARY

Overview

The Woodfolk lab studies the immune response to respiratory viruses.

We use translational models to understand how immune cells respond to viruses in health and disease. We aim to identify biomarkers predicting severe outcomes in at-risk patients and identify new strategies to prevent virus-induced lung damage.

Infection with rhinovirus, the major cause of the common cold, typically runs a benign course. However, in patients with asthma, rhinovirus exposure triggers acute wheezing episodes that often require hospitalization. We have characterized T cells and B cells that define a protective response to rhinovirus and established a previously unrecognized role for type 1 immunity in promoting allergic asthma. The analytical pipelines developed for rhinovirus have since laid the groundwork for work on SARS-CoV-2, the causative agent of COVID-19.

CURRENT LABORATORY MEMBERS

Judith Woodfolk Lab

Judith Woodfolk, GlendaCandera, Lyndsey Muehling, Paul Dell, and Naomi Bryant