Center for Brain Immunology and Glia (BIG)

Scientists in UVA’s Brain Immunology and Glia (BIG) Center are at the forefront of neuroimmunology research. The BIG Center is investigating ways to harness the power of the body’s own immune system to help develop new treatments for Multiple Sclerosis, Autism spectrum disorder, Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease, Depression, Stroke and many other illnesses.

Latest News

Concussion Discovery Reveals Dire Unknown Effect of Even Mild Brain Injuries

Illustration by Alexandra Angelich, University Communications September 2020 - Even mild concussions cause severe and long-lasting impairments in the brain’s ability to clean itself of toxins, and this may seed it…

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Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling

Congratulations to Kate Still and the Harris lab for publishing their recent findings! Click here to read the full article.

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Microglia Regulate Vascular Structure and Function

September 2021 – Congratulations to Drs. Kanchan Bisht and Ukpong Eyo for publishing their research related to microglia, vasculature, and PANX1-P2RY12 in Nature Communications! See the paper at and…

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Support Our Mission

UVA has significantly invested in the Brain Immunology and Glia (BIG) Center, but additional support from private philanthropy will allow us to move more quickly and enhance the impact of our research.

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