Surprise Rheumatoid Arthritis Discovery Points to New Treatment for Joint Inflammation

Kodi Ravichandran and Sanja ArandjelovicKodi Ravichandran, left, and Sanja Arandjelovic led new research into the causes of rheumatoid arthritis flare-ups.

Researchers at the University of Virginia School of Medicine have identified an unexpected contributor to rheumatoid arthritis that may help explain the painful flare-ups associated with the disease.  The new findings about rheumatoid arthritis came in an unexpected fashion. Sanja Arandjelovic, a research scientist in the Ravichandran group, was seeking to better understand what causes the inflammation associated with inflammatory arthritis when she noted that deleting a gene called ELMO1 alleviated arthritis symptoms in mice. This was particularly surprising because Arandjelovic and Ravichandran initially thought that loss of ELMO1 would result in increased inflammation.  [Read more]