A multi-organ chip with matured tissue niches linked by vascular flow

4/18/2023

UVA Author: Karen Hirschi Citation: Ronaldson-Bouchard K, Teles D, Yeager K, Tavakol DN, Zhao Y, Chramiec A, Tagore S, Summers M, Stylianos S, Tamargo M, Lee BM, Halligan SP, Abaci…

A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells

4/18/2023

UVA Author: Karen Hirschi Citation: Coon BG, Timalsina S, Astone M, Zhuang ZW, Fang J, Han J, Themen J, Chung M, Yang-Klingler YJ, Jain M, Hirschi KK, Yamamato A, Trudeau…

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

4/18/2023

UVA Author: Chavkin NW Citation: Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans…

Endothelial cell cycle state determines propensity for arterial-venous fate.

4/18/2023

UVA Author: NW Chavkin Citation: Chavkin NW, Genet G, Poulet M, Jeffery ED, Marziano C, Genet N, Vasavada H, Nelson EA, Acharya BR, Kour A, Aragon J, McDonnell SP, Huba…

Quantitation of RhoA activation: differential binding to downstream effectors

8/24/2022

UVA Author: Yuwen Zhang Citation: Zhang YW, Torsilieri HM, Casanova JE. Quantitation of RhoA activation: differential binding to downstream effectors. Small GTPases. 2022 Jan;13(1):296-306. doi: 10.1080/21541248.2022.2111945. PMID: 35950594; PMCID: PMC9377269.…

Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation

8/11/2022

UVA Author: Chan Choo Yapp Citation: Yap CC, Digilio L, McMahon LP, Wang T, Winckler B. Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation. J Neurosci.…

Lacripep for the Treatment of Primary Sjögren’s-Associated Ocular Surface Disease: Results of the First-In-Human Study

8/11/2022

UVA Author: Gordon Laurie Citation: Tauber J, Laurie GW, Parsons EC, Odrich MG; Lacripep study group*; Lacripep study group*. Lacripep for the Treatment of Primary Sjögren's-Associated Ocular Surface Disease: Results…

Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression

5/20/2022

UVA Author: Faith Karanja Citation: Karanja F, Sahu S, Weintraub S, Bhandari R, Jaszczak R, Sitt J, Halme A. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2115017119. doi:…

Shaylyn Clancy Awarded NIDCD Fellowship

5/20/2022

  Our sense of hearing is critically dependent on the spiral ganglion neurons (SGNs), which connect the sound receptors in the organ of Corti (OC) to the cochlear nuclei of…

Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre

4/21/2022

UVA Author: Ricardo Moraes Borges Citation: Xu PF, Borges RM, Fillatre J, et al. Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nat…