The mating pilus of E. coli pED208 acts as a conduit for ssDNA during horizontal gene transfer

5/29/2025

Authors: Leticia Beltrán 1, Holly Torsilieri 2, Jonasz B Patkowski 3, Jie E Yang 4, James Casanova 2, Tiago R D Costa 3, Elizabeth R Wright 4, Edward H Egelman…

Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of Xenopus mesendoderm

5/15/2025

UVA Author: Tien Comlekoglu Citation: Comlekoglu T, Dzamba BJ, Pacheco GG, Shook DR, Sego TJ, Glazier JA, Peirce SM, DeSimone DW. Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry…

Spatial regulation of mitochondrial membrane potential by α5β1 integrin engagement in collective cell migration

5/15/2025

UVA Author: Gustavo Pacheco Citation: Pacheco GG, Dzamba BJ, Endo W, Edwards BC, Khan M, Comlekoglu T, Shook DR, Quasey K, Bjerke MA, Hirsh GD, Kashatus DF, DeSimone DW. Spatial…

Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure

5/13/2025

UVA Author: Nicholas Chavkin Citation: Horitani K, Chavkin NW, Arai Y, Wang Y, Ogawa H, Yura Y, Evans MA, Cochran JD, Thel MC, Polizio AH, Sano M, Miura-Yura E, Arai…

Tet2-mediated clonal hematopoiesis in non-conditioned mice accelerates age-associated cardiac dysfunction

5/13/2025

UVA Author: Karen Hirschi Citation: Wang Y, Sano S, Yura Y, Ke Z, Sano M, Oshima K, Ogawa H, Horitani K, Min KD, Miura-Yura E, Kour A, Evans MA, Zuriaga…

Tet2-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental stroke

5/13/2025

UVA Author: Nicholas Chavkin Citation: Evans MA, Chavkin NW, Sano S, Sun H, Sardana T, Ravi R, Doviak H, Wang Y, Yura Y, Polizio AH, Horitani K, Ogawa H, Hirschi…

From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations

5/13/2025

UVA Author: Gael Genet Citation: Ricciardelli AR, Genet G, Genet N, McClugage ST 3rd, Kan PT, Hirschi KK, Fish JE, Wythe JD. From bench to bedside: murine models of inherited…

Lacritin cleavage-potentiated targeting of iron – respiratory reciprocity promotes bacterial death

5/13/2025

UVA Author: Mohammed Sharifian Citation: Sharifian Gh M, Norouzi F, Sorci M, Zaidi TS, Pier GB, Achimovich A, Ongwae GM, Liang B, Ryan M, Lemke M, Belfort G, Gadjeva M,…

Salmonella-induced cholesterol accumulation in infected macrophages suppresses autophagy via mTORC1 activation

1/1/2025

Authors: Holly M Torsilieri 1 2, Clint M Upchurch 3, Norbert Leitinger 3, James E Casanova  Citation: Torsilieri HM, Upchurch CM, Leitinger N, Casanova JE. Salmonella-induced cholesterol accumulation in infected macrophages suppresses autophagy via mTORC1 activation. Mol Biol…

General, open-source vertex modeling in biological applications using Tissue Forge

9/23/2024

UVA Author: Tien Comlekoglu Citation: Sego TJ, Comlekoglu T, Peirce SM, Desimone DW, Glazier JA. General, open-source vertex modeling in biological applications using Tissue Forge. Sci Rep. 2023 Oct 19;13(1):17886.…