Prdm6 controls heart development by regulating neural crest cell differentiation and migration
4/21/2022
The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that temporally and spatially…
Convergent extension in the amphibian, Xenopus laevis
4/21/2022
This review is a comprehensive analysis of the cell biology and biomechanics of Convergent Extension in Xenopus.
4/21/2022
Morphogenesis of the vertebrate neural tube occurs by elongation and bending of the neural plate, tissue shape changes that are driven at the cellular level by polarized cell intercalation and…
Convergent extension in mammalian morphogenesis
4/21/2022
Convergent extension is a fundamental morphogenetic process that underlies not only the generation of the elongated vertebrate body plan from the initially radially symmetrical embryo, but also the specific shape…
Pulsed actomyosin contractions in morphogenesis
4/21/2022
Cell and tissue shape changes are the fundamental elements of morphogenesis that drive normal development of embryos into fully functional organisms. This requires a variety of cellular processes including establishment…
Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis
4/21/2022
Herpes stromal keratitis (HSK) is a chronic immunoinflammatory condition which develops in response to recurrent herpes simplex virus-1 (HSV-1) infection of the cornea. Patients with HSK often demonstrate the concurrence…
Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses
4/21/2022
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye. This manuscript explores a…
The Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease
4/21/2022
Homeostasis and visual acuity of the surface of the eye are dependent on tears, a thin film comprising at least 1800 different extracellular proteins and numerous species of lipids through…
4/21/2022
Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at…
Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms
4/21/2022
Purpose: Lacritin is a tear glycoprotein with pro-tearing and pro-ocular surface homeostasis activities that is selectively deficient in most dry eye tears. Proteoforms include an active monomer, inactive polymers, and a…