Lessons from Biology: Engineering Design Considerations for Modeling Human Hematopoiesis

4/18/2023

UVA Author: Nicholas Chavkin Citation: Tavakol, D.N., Chen, J., Chavkin, N.W. et al. Lessons from Biology: Engineering Design Considerations for Modeling Human Hematopoiesis. Curr Stem Cell Rep 7, 174–184 (2021).…

A multi-organ chip with matured tissue niches linked by vascular flow

4/18/2023

UVA Author: Karen Hirschi Citation: Ronaldson-Bouchard K, Teles D, Yeager K, Tavakol DN, Zhao Y, Chramiec A, Tagore S, Summers M, Stylianos S, Tamargo M, Lee BM, Halligan SP, Abaci…

A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells

4/18/2023

UVA Author: Karen Hirschi Citation: Coon BG, Timalsina S, Astone M, Zhuang ZW, Fang J, Han J, Themen J, Chung M, Yang-Klingler YJ, Jain M, Hirschi KK, Yamamato A, Trudeau…

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

4/18/2023

UVA Author: Chavkin NW Citation: Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans…

Endothelial cell cycle state determines propensity for arterial-venous fate.

4/18/2023

UVA Author: NW Chavkin Citation: Chavkin NW, Genet G, Poulet M, Jeffery ED, Marziano C, Genet N, Vasavada H, Nelson EA, Acharya BR, Kour A, Aragon J, McDonnell SP, Huba…

Quantitation of RhoA activation: differential binding to downstream effectors

8/24/2022

UVA Author: Yuwen Zhang Citation: Zhang YW, Torsilieri HM, Casanova JE. Quantitation of RhoA activation: differential binding to downstream effectors. Small GTPases. 2022 Jan;13(1):296-306. doi: 10.1080/21541248.2022.2111945. PMID: 35950594; PMCID: PMC9377269.…

Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation

8/11/2022

UVA Author: Chan Choo Yapp Citation: Yap CC, Digilio L, McMahon LP, Wang T, Winckler B. Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation. J Neurosci.…

Lacripep for the Treatment of Primary Sjögren’s-Associated Ocular Surface Disease: Results of the First-In-Human Study

8/11/2022

UVA Author: Gordon Laurie Citation: Tauber J, Laurie GW, Parsons EC, Odrich MG; Lacripep study group*; Lacripep study group*. Lacripep for the Treatment of Primary Sjögren's-Associated Ocular Surface Disease: Results…

Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression

5/20/2022

UVA Author: Faith Karanja Citation: Karanja F, Sahu S, Weintraub S, Bhandari R, Jaszczak R, Sitt J, Halme A. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2115017119. doi:…

Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre

4/21/2022

UVA Author: Ricardo Moraes Borges Citation: Xu PF, Borges RM, Fillatre J, et al. Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nat…