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Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates

5/30/2024

Background: Sperm acrosomal SLLP1 binding (SAS1B) protein is found in oocytes, which is necessary for sperm-oocyte interaction, and also in uterine and pancreatic cancers. Anti-SAS1B antibody-drug conjugates (ADCs) arrested growth in these cancers.…

The Chlamydomonas flagellar membrane and its dynamic properties

5/2/2024

This chapter overviews a membrane bound organelle and describes its dynamic properties. The plasma membrane of a Chlamydomonas cell must have at least two domains. The Chlamydomonas flagellar membrane is a sub-domain of and…

Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

3/25/2024

Background: Distinct endothelial cell cycle states (early G1 versus late G1) provide different "windows of opportunity" to enable the differential expression of genes that regulate venous versus arterial specification, respectively.…

Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction

3/25/2024

Background: Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse…

Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans

3/25/2024

Introduction: Vascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an endothelial-to-mesenchymal transition (EndoMT), where endothelial cells undergo a phenotypic switch to mesenchymal-like…

Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium

3/25/2024

Endothelial cells (ECs) adapt to the unique needs of their resident tissue and metabolic perturbations, such as obesity. We sought to understand how obesity affects EC metabolic phenotypes, specifically mitochondrial…

Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages

3/25/2024

Tissue resident macrophages are largely of embryonic (fetal liver) origin and long-lived, while bone marrow-derived macrophages (BMDM) are recruited following an acute perturbation, such as hypoxia in the setting of…

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

3/25/2024

Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic…

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

3/25/2024

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm,…

Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

6/14/2023

Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest lack mechanistic understanding. We previously showed that arterial shear stress up-regulates Cx37 in endothelial cells and activates a Notch/Cx37/p27 signaling…